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Details on Person TRAF6/or TRAF2 ubiquitination within dsRNA:Mda5:Ips1:Traf6/ or Traf2 complex

Class:Id	BlackBoxEvent:1227769
_displayName	TRAF6/or TRAF2 ubiquitination within dsRNA:Mda5:Ips1:Traf6/ or Traf2 complex
_doRelease	TRUE
_timestamp	2017-08-02 19:26:17
authored	[InstanceEdit:1168652] Shamovsky, V, 2011-01-04
catalystActivity	[CatalystActivity:1227771] ubiquitin-ubiquitin ligase activity of dsRNA:MDA5:IPS1:TRAF6/TRAF2 [mitochondrial outer membrane]
compartment	[Compartment:17906] mitochondrial outer membrane [Compartment:70101] cytosol
created	[InstanceEdit:1227772] Shamovsky, V, 2011-03-10
edited	[InstanceEdit:1280191] Shamovsky, V, 2011-05-11
inferredFrom	[Reaction:918230] Recruitment of TRAF6/TRAF2 to MAVS [Homo sapiens]
input	[Polymer:434061] K63_polyubiquitin chain [cytosol] [Gallus gallus] [Polymer:434061] K63_polyubiquitin chain [cytosol] [Gallus gallus] [DefinedSet:1267865] dsRNA:MDA5:IPS1:TRAF6/or TRAF2 [mitochondrial outer membrane] [Gallus gallus]
isChimeric	FALSE
literatureReference	[LiteratureReference:202511] Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation [LiteratureReference:1250152] Virus-triggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of interferon-beta (IFN-beta) and cellular antiviral response [LiteratureReference:208040] Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
modified	[InstanceEdit:1227902] Shamovsky, V, 2011-03-10 [InstanceEdit:1247366] Shamovsky, V, 2011-04-01 [InstanceEdit:1267866] Shamovsky, V, 2011-05-09 [InstanceEdit:1295510] Shamovsky, V, 2011-05-17 [InstanceEdit:1300654] Shamovsky, V, 2011-05-23 [InstanceEdit:9014711] Shamovsky, Veronica, 2017-08-02 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TRAF6/or TRAF2 ubiquitination within dsRNA:Mda5:Ips1:Traf6/ or Traf2 complex
output	[DefinedSet:1227773] dsRNA:MDA5:IPS1:K63-linked pUb TRAF6 or TRAF2 [mitochondrial outer membrane] [Gallus gallus]
precedingEvent	[Reaction:1227775] TRAF6/or TRAF2 interacts with IPS-1 [Gallus gallus] [Reaction:1227709] Activated MDA5 binds IPS-1 [Gallus gallus]
relatedSpecies	[Species:9014381] Infectious bronchitis virus
releaseDate	2011-06-14
requiredInputComponent	[Complex:446245] Ubiquitin:UBE2N : UBE2V complex [cytosol] [Gallus gallus]
reviewed	[InstanceEdit:1295492] Garapati, P V, 2011-05-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:1357586] R-GGA-1227769.3
summation	[Summation:1267868] TRAFs are E3 ubiquitin ligases that bind to an E2 - ubiquiti...
(hasEvent)	[Pathway:1227892] TRAF6 mediated NF-kB activation [Gallus gallus]
(precedingEvent)	[Reaction:1227778] MEKK1 binds TRAF6 [Gallus gallus]
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No pathways have been reviewed or authored by TRAF6/or TRAF2 ubiquitination within dsRNA:Mda5:Ips1:Traf6/ or Traf2 complex (1227769)