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Details on Person Caspase 8 or 10 recruitment to IPS1 complex followed by their dimerization

Class:Id	Reaction:1227753
_displayName	Caspase 8 or 10 recruitment to IPS1 complex followed by their dimerization
_doRelease	TRUE
_timestamp	2017-08-02 19:24:43
authored	[InstanceEdit:1168652] Shamovsky, V, 2011-01-04
compartment	[Compartment:17906] mitochondrial outer membrane [Compartment:70101] cytosol
created	[InstanceEdit:1227751] Shamovsky, V, 2011-03-10
edited	[InstanceEdit:1280191] Shamovsky, V, 2011-05-11
inferredFrom	[Reaction:933526] Recruitment of caspase-8 and -10 to FADD complex [Homo sapiens] [Reaction:933523] Dimerzation of procaspase-8, procaspase-10 [Homo sapiens]
input	[Complex:1227731] dsRNA:MDA5:IPS1:TRADD:FADD:RIP1 [mitochondrial outer membrane] [Gallus gallus] [DefinedSet:1227752] procaspase 8 or 10 [cytosol] [Gallus gallus] [DefinedSet:1227752] procaspase 8 or 10 [cytosol] [Gallus gallus]
isChimeric	FALSE
literatureReference	[LiteratureReference:933424] Activation of the NF-kappaB pathway by caspase 8 and its homologs [LiteratureReference:933437] Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases [LiteratureReference:933435] Caspases leave the beaten track: caspase-mediated activation of NF-kappaB [LiteratureReference:933506] Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA
modified	[InstanceEdit:1267857] Shamovsky, V, 2011-05-09 [InstanceEdit:1295510] Shamovsky, V, 2011-05-17 [InstanceEdit:1300654] Shamovsky, V, 2011-05-23 [InstanceEdit:9014711] Shamovsky, Veronica, 2017-08-02 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Caspase 8 or 10 recruitment to IPS1 complex followed by their dimerization
output	[Complex:1227749] dsRNA:MDA5:IPS1:TRADD:FADD:RIP1:procaspase 8 or 10 dimer [mitochondrial outer membrane] [Gallus gallus]
precedingEvent	[Reaction:1227732] IPS1 interacts with TRADD, RIP1 and FADD [Gallus gallus] [Reaction:1227709] Activated MDA5 binds IPS-1 [Gallus gallus]
relatedSpecies	[Species:9014381] Infectious bronchitis virus
releaseDate	2011-06-14
reviewed	[InstanceEdit:1295492] Garapati, P V, 2011-05-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:1357537] R-GGA-1227753.3
summation	[Summation:1267834] Induction of inflammatory cytokines in response to poly(I:C)...
(hasEvent)	[Pathway:1227739] Caspase-8 and -10 mediated induction of NF-kB [Gallus gallus]
(precedingEvent)	[Reaction:1227755] Recruitment of IKK complex [Gallus gallus]
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No pathways have been reviewed or authored by Caspase 8 or 10 recruitment to IPS1 complex followed by their dimerization (1227753)