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Details on Person dsRNA binds to MDA5

Class:IdReaction:1227694
_displayNamedsRNA binds to MDA5
_doReleaseTRUE
_timestamp2017-07-28 04:30:49
authored[InstanceEdit:1168652] Shamovsky, V, 2011-01-04
compartment[Compartment:70101] cytosol
created[InstanceEdit:1227707] Shamovsky, V, 2011-03-10
edited[InstanceEdit:1280191] Shamovsky, V, 2011-05-11
inferredFrom
input[Complex:1227696] MDA5 : DAK [cytosol] [Gallus gallus]
[Complex:1227696] MDA5 : DAK [cytosol] [Gallus gallus]
[GenomeEncodedEntity:9014385] IBV dsRNA intermediate form [cytosol] [Infectious bronchitis virus]
isChimericFALSE
literatureReference[LiteratureReference:1227693] Association of RIG-I with innate immunity of ducks to influenza
[LiteratureReference:1237382] mda-5, but not RIG-I, is a common target for paramyxovirus V proteins
[LiteratureReference:918206] Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase
[LiteratureReference:9014372] Activation of the chicken type I interferon response by infectious bronchitis coronavirus
modified[InstanceEdit:1227902] Shamovsky, V, 2011-03-10
[InstanceEdit:1237405] Shamovsky, V, 2011-03-30
[InstanceEdit:1295510] Shamovsky, V, 2011-05-17
[InstanceEdit:1300654] Shamovsky, V, 2011-05-23
[InstanceEdit:6790582] Shamovsky, Veronica, 2015-08-13
[InstanceEdit:9014389] Shamovsky, Veronica, 2017-07-28
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namedsRNA binds to MDA5
output[Complex:1227681] viral dsRNA:MDA5 [cytosol] [Gallus gallus]
[EntityWithAccessionedSequence:1227706] Dihydroxyacetone kinase (DAK) [cytosol] [Gallus gallus]
[EntityWithAccessionedSequence:1227706] Dihydroxyacetone kinase (DAK) [cytosol] [Gallus gallus]
relatedSpecies[Species:9014381] Infectious bronchitis virus
releaseDate2011-06-14
reviewed[InstanceEdit:1295492] Garapati, P V, 2011-05-16
reviewStatus[ReviewStatus:9821382] five stars
species[Species:49591] Gallus gallus
stableIdentifier[StableIdentifier:1357515] R-GGA-1227694.4
summation[Summation:1237363] Poly(I)-poly(C) was reported to trigger MDA5 mediated IFN si...
(hasEvent)[Pathway:1227887] RLR (RIG-like receptor) mediated induction of IFN alpha/beta [Gallus gallus]
(precedingEvent)[Reaction:1227695] NLRC5 binds to CARD domain of Mda5 and prevents IPS1 binding [Gallus gallus]
[Reaction:1227709] Activated MDA5 binds IPS-1 [Gallus gallus]
(updatedInstance)[_UpdateTracker:9780618] Update Tracker - [Reaction:1227694] dsRNA binds to MDA5 - v62:[addLiteratureReference, add_removeInput]
[_UpdateTracker:9784508] Update Tracker - [Reaction:1227694] dsRNA binds to MDA5 - v54:[add_removeInput]
[_UpdateTracker:9864030] Update Tracker - [Reaction:1227694] dsRNA binds to MDA5 - v88:[modifyText]
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