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Details on Person Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants
Class:Id Reaction:1226014 _displayName Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants _doRelease TRUE _timestamp 2014-11-13 18:52:31 authored [InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04 catalystActivity [CatalystActivity:1226011] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1:PI3K [plasma membrane] compartment [Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region created [InstanceEdit:1226010] Orlic-Milacic, Marija, 2011-03-04 disease [Disease:1500689] cancer edited [InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07 entityFunctionalStatus [EntityFunctionalStatus:5637722] gain_of_function of Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1:PI3K [plasma membrane] input [SimpleEntity:179856] PI(4,5)P2 [plasma membrane] [SimpleEntity:113592] ATP [cytosol] isChimeric FALSE literatureReference [LiteratureReference:1225829] Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways [LiteratureReference:1217508] Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins [LiteratureReference:2008136] Sensitivity of epidermal growth factor receptor and ErbB2 exon 20 insertion mutants to Hsp90 inhibition [LiteratureReference:1181018] Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants [LiteratureReference:2008165] Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain [LiteratureReference:1228027] EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy modified [InstanceEdit:1226065] Orlic-Milacic, Marija, 2011-03-07 [InstanceEdit:1235103] Orlic-Milacic, Marija, 2011-03-23 [InstanceEdit:1246120] Orlic-Milacic, Marija, 2011-04-01 [InstanceEdit:1247352] Orlic-Milacic, Marija, 2011-04-01 [InstanceEdit:1247850] Orlic-Milacic, Marija, 2011-04-07 [InstanceEdit:1247851] Orlic-Milacic, Marija, 2011-04-07 [InstanceEdit:1614296] Orlic-Milacic, Marija, 2011-09-28 [InstanceEdit:1643718] Orlic-Milacic, Marija, 2011-10-11 [InstanceEdit:1660492] Orlic-Milacic, Marija, 2011-10-13 [InstanceEdit:1660495] Orlic-Milacic, Marija, 2011-10-13 [InstanceEdit:1667628] Orlic-Milacic, Marija, 2011-10-14 [InstanceEdit:1979631] Orlic-Milacic, Marija, 2011-11-08 [InstanceEdit:1990842] Orlic-Milacic, Marija, 2011-11-14 [InstanceEdit:1990860] Orlic-Milacic, Marija, 2011-11-14 [InstanceEdit:1996353] Orlic-Milacic, Marija, 2011-11-19 [InstanceEdit:2008065] Orlic-Milacic, Marija, 2011-11-21 [InstanceEdit:2008173] Orlic-Milacic, Marija, 2011-11-21 [InstanceEdit:2023591] Matthews, L, 2011-12-09 [InstanceEdit:3095949] Orlic-Milacic, M, 2013-02-08 [InstanceEdit:5637816] Orlic-Milacic, Marija, 2014-11-12 [InstanceEdit:5638335] Orlic-Milacic, Marija, 2014-11-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants normalReaction
output [SimpleEntity:179838] PI(3,4,5)P3 [plasma membrane] [SimpleEntity:29370] ADP [cytosol] precedingEvent
releaseDate 2011-12-06 reviewed [InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:2016450] R-HSA-1226014.2 summation [Summation:1247349] The kinase activity of PI3K mediates the phosphorylation of ... (hasEvent) [Pathway:1169434] Signaling by constitutively active EGFR kinase domain mutants [Homo sapiens] [Pathway:1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants [Homo sapiens] (updatedInstance) [_UpdateTracker:9835700] Update Tracker - [Reaction:1226014] Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants - v85:[modifyText]
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