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Details on Person Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants
Class:Id Reaction:1226012 _displayName Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants _doRelease TRUE _timestamp 2018-11-28 19:29:29 authored [InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04 compartment [Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane created [InstanceEdit:1226010] Orlic-Milacic, Marija, 2011-03-04 disease [Disease:1500689] cancer edited [InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07 entityFunctionalStatus [EntityFunctionalStatus:5637725] gain_of_function of Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1 [plasma membrane] input [Complex:1226015] Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1 [plasma membrane] [Homo sapiens] [Complex:1806218] PIK3CA:PIK3R1 [cytosol] [Homo sapiens] isChimeric FALSE literatureReference [LiteratureReference:1225829] Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways modified [InstanceEdit:1246117] Orlic-Milacic, Marija, 2011-04-01 [InstanceEdit:1247351] Orlic-Milacic, Marija, 2011-04-01 [InstanceEdit:1247595] Orlic-Milacic, Marija, 2011-04-04 [InstanceEdit:1247850] Orlic-Milacic, Marija, 2011-04-07 [InstanceEdit:1247851] Orlic-Milacic, Marija, 2011-04-07 [InstanceEdit:1614294] Orlic-Milacic, Marija, 2011-09-28 [InstanceEdit:1643716] Orlic-Milacic, Marija, 2011-10-11 [InstanceEdit:1660492] Orlic-Milacic, Marija, 2011-10-13 [InstanceEdit:1660495] Orlic-Milacic, Marija, 2011-10-13 [InstanceEdit:1979631] Orlic-Milacic, Marija, 2011-11-08 [InstanceEdit:1990842] Orlic-Milacic, Marija, 2011-11-14 [InstanceEdit:1990860] Orlic-Milacic, Marija, 2011-11-14 [InstanceEdit:1996351] Orlic-Milacic, Marija, 2011-11-19 [InstanceEdit:2023591] Matthews, L, 2011-12-09 [InstanceEdit:3095949] Orlic-Milacic, M, 2013-02-08 [InstanceEdit:5637816] Orlic-Milacic, Marija, 2014-11-12 [InstanceEdit:5638335] Orlic-Milacic, Marija, 2014-11-13 [InstanceEdit:9630102] Orlic-Milacic, Marija, 2018-11-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants normalReaction
output [Complex:1226013] Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1:PI3K [plasma membrane] [Homo sapiens] precedingEvent
releaseDate 2011-12-06 reviewed [InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:2016570] R-HSA-1226012.3 summation [Summation:1247350] EGFR cancer mutants are assumed to recruit the PI3K complex ... (hasEvent) [Pathway:1169434] Signaling by constitutively active EGFR kinase domain mutants [Homo sapiens] [Pathway:1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants [Homo sapiens] (precedingEvent) [Reaction:1226014] Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants [Homo sapiens] (updatedInstance) [_UpdateTracker:9778680] Update Tracker - [Reaction:1226012] Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants - v68:[add_removeInput, modifyText]
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