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Details on Person Activin binds the Activin receptor composed of a type II rec...
| Class:Id | Summation:1225984 |
|---|---|
| _displayName | Activin binds the Activin receptor composed of a type II rec... |
| _timestamp | 2023-08-21 15:19:47 |
| created | [InstanceEdit:1225996] May, B, 2011-03-04 |
| literatureReference | [LiteratureReference:9840171] Inhibin is an antagonist of bone morphogenetic protein signaling [LiteratureReference:9842165] Betaglycan binds inhibin and can mediate functional antagonism of activin signalling |
| modified | [InstanceEdit:2470509] May, B, 2012-09-18 [InstanceEdit:2484921] May, B, 2012-09-26 [InstanceEdit:9842163] Tiwari, Krishna, 2023-08-21 [InstanceEdit:9842171] Orlic-Milacic, Marija, 2023-08-21 |
| text | Activin binds the Activin receptor composed of a type II receptor (ACVR2A/B) and a type I receptor, in this case ACVR1B (ALK4) (Attisano et al. 1996, Zhou et al. 2000). Activin appears to interact initially with the type II receptor component (Attisano et al. 1996). It is unclear if the type II and type I receptors are associated before binding Activin. Any of Activin A (INHBA:INHBA), Activin AB (INHBA:INHBB), and Activin B (INHBB:INHBB) can bind and signal via an activin receptor containing the ACVR1B (ALK4) type I receptor. Also, TGFBR3 (Betaglycan) antagonises Activin signalling by binding with Inhibin A and ACVR2A (ActRII). TGFBR3 and Activin compete for ACVR2A and TGFBR3 thus inhibits activin signalling (Lewis et al. 2000, Waiter et al. 2003). |
| (summation) | [Reaction:1181153] Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B [Homo sapiens] |
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No pathways have been reviewed or authored by Activin binds the Activin receptor composed of a type II rec... (1225984)
