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Details on Person Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers

Class:Id	Reaction:1225978
_displayName	Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers
_doRelease	TRUE
_timestamp	2024-03-19 12:24:31
authored	[InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:1225980] Orlic-Milacic, Marija, 2011-03-03
disease	[Disease:1500689] cancer
edited	[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07
input	[DefinedSet:1216522] Covalent EGFR tyrosine kinase inhibitors [cytosol] [DefinedSet:1216522] Covalent EGFR tyrosine kinase inhibitors [cytosol] [Complex:9624420] EGF-like ligands:EGFR dimer [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1225967] Novel mutant-selective EGFR kinase inhibitors against EGFR T790M
modified	[InstanceEdit:1226006] Orlic-Milacic, Marija, 2011-03-04 [InstanceEdit:1247613] Orlic-Milacic, Marija, 2011-04-04 [InstanceEdit:1643693] Orlic-Milacic, Marija, 2011-10-11 [InstanceEdit:1660495] Orlic-Milacic, Marija, 2011-10-13 [InstanceEdit:1979631] Orlic-Milacic, Marija, 2011-11-08 [InstanceEdit:1990842] Orlic-Milacic, Marija, 2011-11-14 [InstanceEdit:1990860] Orlic-Milacic, Marija, 2011-11-14 [InstanceEdit:2023591] Matthews, L, 2011-12-09 [InstanceEdit:9624437] Rothfels, Karen, 2018-10-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9865824] Orlic-Milacic, Marija, 2024-03-19
name	Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers
negativePrecedingEvent	[NegativePrecedingEvent:9865811] Futile Cycle: PTPRK dephosphorylates p-6Y-EGFR
output	[Complex:1225979] EGF-like ligands:EGFR Dimer:Covalent EGFR TKIs [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:177922] EGFR dimerization [Homo sapiens] [Reaction:177942] EGFR binds EGF ligand [Homo sapiens] [Reaction:9674531] AAMP binds EGFR [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016662] R-HSA-1225978.4
summation	[Summation:1247599] Covalent (irreversible) TKIs, pelitinib, WZ4002, HKI-272, ca...
(hasEvent)	[Pathway:1169434] Signaling by constitutively active EGFR kinase domain mutants [Homo sapiens] [Pathway:5638303] Inhibition of Signaling by Overexpressed EGFR [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9778950] Update Tracker - [Reaction:1225978] Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers - v67:[add_removeInput]
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