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Details on Person Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex

Class:Id	Reaction:1225961
_displayName	Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex
_doRelease	TRUE
_timestamp	2014-11-13 18:52:32
authored	[InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1225955] Orlic-Milacic, Marija, 2011-03-03
disease	[Disease:1500689] cancer
edited	[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07
entityFunctionalStatus	[EntityFunctionalStatus:5637727] gain_of_function of Ligand-responsive p-6Y-EGFR mutants:p-Y349,350-SHC1 [plasma membrane]
input	[Complex:109797] GRB2-1:SOS1 [cytosol] [Homo sapiens] [Complex:1225854] Ligand-responsive p-6Y-EGFR mutants:p-Y349,350-SHC1 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:179827] Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
modified	[InstanceEdit:1236375] Orlic-Milacic, Marija, 2011-03-24 [InstanceEdit:1246115] Orlic-Milacic, Marija, 2011-04-01 [InstanceEdit:1247553] Orlic-Milacic, Marija, 2011-04-01 [InstanceEdit:1247614] Orlic-Milacic, Marija, 2011-04-04 [InstanceEdit:1247630] Orlic-Milacic, Marija, 2011-04-04 [InstanceEdit:1247850] Orlic-Milacic, Marija, 2011-04-07 [InstanceEdit:1247851] Orlic-Milacic, Marija, 2011-04-07 [InstanceEdit:1614299] Orlic-Milacic, Marija, 2011-09-28 [InstanceEdit:1643721] Orlic-Milacic, Marija, 2011-10-11 [InstanceEdit:1660495] Orlic-Milacic, Marija, 2011-10-13 [InstanceEdit:1979631] Orlic-Milacic, Marija, 2011-11-08 [InstanceEdit:1990842] Orlic-Milacic, Marija, 2011-11-14 [InstanceEdit:1990860] Orlic-Milacic, Marija, 2011-11-14 [InstanceEdit:1996369] Orlic-Milacic, Marija, 2011-11-19 [InstanceEdit:2008138] Orlic-Milacic, Marija, 2011-11-21 [InstanceEdit:2023591] Matthews, L, 2011-12-09 [InstanceEdit:3095949] Orlic-Milacic, M, 2013-02-08 [InstanceEdit:5637816] Orlic-Milacic, Marija, 2014-11-12 [InstanceEdit:5638335] Orlic-Milacic, Marija, 2014-11-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex
normalReaction	[Reaction:177936] GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR [Homo sapiens]
output	[Complex:1225856] Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1225952] Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants [Homo sapiens] [Reaction:1225947] Binding of SHC1 to p-6Y-EGFR mutants [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016128] R-HSA-1225961.2
summation	[Summation:1247551] Recruitment of GRB2:SOS1 complex by SHC1 bound to phosphoryl...
(hasEvent)	[Pathway:1169434] Signaling by constitutively active EGFR kinase domain mutants [Homo sapiens] [Pathway:1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants [Homo sapiens]
(precedingEvent)	[Reaction:1225957] SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants) [Homo sapiens]
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