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Details on Person Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants

Class:Id	Reaction:1225950
_displayName	Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants
_doRelease	TRUE
_timestamp	2014-11-13 18:52:30
authored	[InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region [Compartment:70101] cytosol
created	[InstanceEdit:1225955] Orlic-Milacic, Marija, 2011-03-03
disease	[Disease:1500689] cancer
edited	[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07
entityFunctionalStatus	[EntityFunctionalStatus:5637728] gain_of_function of Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane]
input	[Complex:109797] GRB2-1:SOS1 [cytosol] [Homo sapiens] [DefinedSet:1181062] Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1225829] Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways [LiteratureReference:1181018] Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants [LiteratureReference:2008136] Sensitivity of epidermal growth factor receptor and ErbB2 exon 20 insertion mutants to Hsp90 inhibition [LiteratureReference:2008165] Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain [LiteratureReference:1181035] Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib [LiteratureReference:1181048] EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib [LiteratureReference:1225923] Association with HSP90 inhibits Cbl-mediated down-regulation of mutant epidermal growth factor receptors [LiteratureReference:2008166] EGF-independent activation of cell-surface EGF receptors harboring mutations found in gefitinib-sensitive lung cancer [LiteratureReference:1248643] Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma
modified	[InstanceEdit:1246114] Orlic-Milacic, Marija, 2011-04-01 [InstanceEdit:1247850] Orlic-Milacic, Marija, 2011-04-07 [InstanceEdit:1247851] Orlic-Milacic, Marija, 2011-04-07 [InstanceEdit:1500867] Orlic-Milacic, Marija, 2011-08-22 [InstanceEdit:1614293] Orlic-Milacic, Marija, 2011-09-28 [InstanceEdit:1643715] Orlic-Milacic, Marija, 2011-10-11 [InstanceEdit:1660495] Orlic-Milacic, Marija, 2011-10-13 [InstanceEdit:1979631] Orlic-Milacic, Marija, 2011-11-08 [InstanceEdit:1990842] Orlic-Milacic, Marija, 2011-11-14 [InstanceEdit:1990860] Orlic-Milacic, Marija, 2011-11-14 [InstanceEdit:1996350] Orlic-Milacic, Marija, 2011-11-19 [InstanceEdit:2008164] Orlic-Milacic, Marija, 2011-11-21 [InstanceEdit:2008182] Orlic-Milacic, Marija, 2011-11-21 [InstanceEdit:2023591] Matthews, L, 2011-12-09 [InstanceEdit:3095949] Orlic-Milacic, M, 2013-02-08 [InstanceEdit:5637816] Orlic-Milacic, Marija, 2014-11-12 [InstanceEdit:5638335] Orlic-Milacic, Marija, 2014-11-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants Binding of GRB2:SOS1 to ligand-responsive p-6Y-EGFR mutants
normalReaction	[Reaction:177943] GRB2:SOS1 complex binds to EGF:EGFR complex [Homo sapiens]
output	[Complex:1225859] Ligand-responsive p-6Y-EGFR mutants:GRB2:SOS1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1169421] Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers [Homo sapiens] [Reaction:1220613] EGF-induced dimerization of ligand-responsive EGFR mutants [Homo sapiens] [Reaction:1220614] Spontaneous dimerization of ligand-responsive EGFR mutants [Homo sapiens] [Reaction:1248655] Trans-autophosphorylation of EGFRvIII mutant dimers [Homo sapiens] [Reaction:1248002] Ligand-independent dimerization of EGFRvIII mutant [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016707] R-HSA-1225950.2
summation	[Summation:1225943] Direct binding of GRB2:SOS1 complex to phosphorylated homodi...
(hasEvent)	[Pathway:1169434] Signaling by constitutively active EGFR kinase domain mutants [Homo sapiens] [Pathway:1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants [Homo sapiens]
(precedingEvent)	[Reaction:1225951] SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9785585] Update Tracker - [Reaction:1225950] Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants - v51:[add_removeInput] [_UpdateTracker:9835691] Update Tracker - [Reaction:1225950] Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants - v85:[modifyText]
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