Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person Binding of CBL to ligand-responsive p-6Y-EGFR mutants

Class:Id	Reaction:1225949
_displayName	Binding of CBL to ligand-responsive p-6Y-EGFR mutants
_doRelease	TRUE
_timestamp	2018-12-19 15:20:23
authored	[InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:1225955] Orlic-Milacic, Marija, 2011-03-03
disease	[Disease:1500689] cancer
edited	[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990852] Gillespie, ME, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07
entityFunctionalStatus	[EntityFunctionalStatus:5637728] gain_of_function of Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane]
input	[DefinedSet:1181062] Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:112199] CBL [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:112199] CBL [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1225829] Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways [LiteratureReference:1225925] Epidermal growth factor receptors with tyrosine kinase domain mutations exhibit reduced Cbl association, poor ubiquitylation, and down-regulation but are efficiently internalized [LiteratureReference:1225923] Association with HSP90 inhibits Cbl-mediated down-regulation of mutant epidermal growth factor receptors [LiteratureReference:1248637] Hypophosphorylation of residue Y1045 leads to defective downregulation of EGFRvIII [LiteratureReference:2008120] EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes [LiteratureReference:1181018] Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants [LiteratureReference:2008166] EGF-independent activation of cell-surface EGF receptors harboring mutations found in gefitinib-sensitive lung cancer [LiteratureReference:2008165] Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain [LiteratureReference:2008136] Sensitivity of epidermal growth factor receptor and ErbB2 exon 20 insertion mutants to Hsp90 inhibition
modified	[InstanceEdit:1235092] Orlic-Milacic, Marija, 2011-03-23 [InstanceEdit:1246111] Orlic-Milacic, Marija, 2011-04-01 [InstanceEdit:1247850] Orlic-Milacic, Marija, 2011-04-07 [InstanceEdit:1247851] Orlic-Milacic, Marija, 2011-04-07 [InstanceEdit:1643689] Orlic-Milacic, Marija, 2011-10-11 [InstanceEdit:1660495] Orlic-Milacic, Marija, 2011-10-13 [InstanceEdit:1979631] Orlic-Milacic, Marija, 2011-11-08 [InstanceEdit:1990842] Orlic-Milacic, Marija, 2011-11-14 [InstanceEdit:1990854] Orlic-Milacic, Marija, 2011-11-14 [InstanceEdit:1990860] Orlic-Milacic, Marija, 2011-11-14 [InstanceEdit:1998737] Orlic-Milacic, Marija, 2011-11-19 [InstanceEdit:2008180] Orlic-Milacic, Marija, 2011-11-21 [InstanceEdit:2023591] Matthews, L, 2011-12-09 [InstanceEdit:5637816] Orlic-Milacic, Marija, 2014-11-12 [InstanceEdit:5638335] Orlic-Milacic, Marija, 2014-11-13 [InstanceEdit:9632499] Orlic-Milacic, Marija, 2018-12-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Binding of CBL to ligand-responsive p-6Y-EGFR mutants
normalReaction	[Reaction:183055] Binding of CBL to EGFR [Homo sapiens]
output	[Complex:1225855] Ligand-responsive p-6Y-EGFR mutants:CBL [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1169421] Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers [Homo sapiens] [Reaction:1220613] EGF-induced dimerization of ligand-responsive EGFR mutants [Homo sapiens] [Reaction:1220614] Spontaneous dimerization of ligand-responsive EGFR mutants [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016180] R-HSA-1225949.3
summation	[Summation:1225953] CBL binds to phosphorylated tyrosine Y1069 (i.e. Y1045 in th...
(hasEvent)	[Pathway:1169434] Signaling by constitutively active EGFR kinase domain mutants [Homo sapiens] [Pathway:1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants [Homo sapiens]
(precedingEvent)	[Reaction:1225960] Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9778078] Update Tracker - [Reaction:1225949] Binding of CBL to ligand-responsive p-6Y-EGFR mutants - v68:[add_removeInput] [_UpdateTracker:9835775] Update Tracker - [Reaction:1225949] Binding of CBL to ligand-responsive p-6Y-EGFR mutants - v85:[modifyText] [_UpdateTracker:9846766] Update Tracker - [Reaction:1225949] Binding of CBL to ligand-responsive p-6Y-EGFR mutants - v84:[modifyText]
[Change default viewing format]

No pathways have been reviewed or authored by Binding of CBL to ligand-responsive p-6Y-EGFR mutants (1225949)