Query author contributions in Reactome
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Details on Person SOS is the guanine nucleotide exchange factor (GEF) for Ras....
| Class:Id | Summation:1225942 |
|---|---|
| _displayName | SOS is the guanine nucleotide exchange factor (GEF) for Ras.... |
| _timestamp | 2011-04-01 19:54:21 |
| created | [InstanceEdit:1225955] Orlic-Milacic, Marija, 2011-03-03 |
| literatureReference | [LiteratureReference:1225829] Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways [LiteratureReference:1181018] Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants |
| modified | [InstanceEdit:1236380] Orlic-Milacic, Marija, 2011-03-24 [InstanceEdit:1247553] Orlic-Milacic, Marija, 2011-04-01 |
| text | SOS is the guanine nucleotide exchange factor (GEF) for Ras. SOS, recruited by GRB2 bound to phospho-SHC1:phospho-EGFR KD mutants, activates Ras nucleotide exchange from the inactive form (bound to GDP) to an active form (bound to GTP). |
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No pathways have been reviewed or authored by SOS is the guanine nucleotide exchange factor (GEF) for Ras.... (1225942)
