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Details on Person Phospho R-SMAD(SMAD2,3):CO-SMAD(SMAD4):FOXH1 binds Activin Response Element

Class:Id	Reaction:1225919
_displayName	Phospho R-SMAD(SMAD2,3):CO-SMAD(SMAD4):FOXH1 binds Activin Response Element
_doRelease	TRUE
_timestamp	2021-03-08 16:50:26
authored	[InstanceEdit:1225902] May, B, 2011-02-13
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:1225868] May, B, 2011-03-03
edited	[InstanceEdit:1225902] May, B, 2011-02-13
inferredFrom	[Reaction:9717136] p-Smad2,3:Smad4:Foxh1 binds Activin Response Element [Mus musculus]
input	[DefinedSet:173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:1225914] FOXH1 [nucleoplasm] [Homo sapiens] [OtherEntity:1225892] Activin Response Element [nucleoplasm]
isChimeric	FALSE
literatureReference	[LiteratureReference:1225889] Characterization of human FAST-1, a TGF beta and activin signal transducer [LiteratureReference:1225921] Heterogeneities in the biological and biochemical functions of Smad2 and Smad4 mutants naturally occurring in human lung cancers [LiteratureReference:2584289] Smad4 and FAST-1 in the assembly of activin-responsive factor [LiteratureReference:2584293] A transcriptional partner for MAD proteins in TGF-beta signalling [LiteratureReference:2584283] The role of FAST-1 and Smads in transcriptional regulation by activin during early Xenopus embryogenesis
modified	[InstanceEdit:1433619] May, B, 2011-07-12 [InstanceEdit:1498828] May, B, 2011-08-18 [InstanceEdit:1529117] May, B, 2011-08-24 [InstanceEdit:2584310] May, B, 2012-11-14 [InstanceEdit:2584313] May, B, 2012-11-14 [InstanceEdit:5251385] May, B, 2014-02-03 [InstanceEdit:8858361] Jupe, Steve, 2016-02-18 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9717146] May, Bruce, 2021-03-04 [InstanceEdit:9717243] May, Bruce, 2021-03-08 [InstanceEdit:9733355] Wu, Guanming, 2021-06-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phospho R-SMAD(SMAD2,3):CO-SMAD(SMAD4):FOXH1 binds Activin Response Element
output	[Complex:1225870] SMAD2,3:SMAD4:FOXH1:Activin Response Element [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:173488] The SMAD2/3:SMAD4 complex transfers to the nucleus [Homo sapiens] [Reaction:170847] Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 [Homo sapiens]
regulatedBy	[NegativeRegulation:1226032] Negative regulation by 'FOXH1:DRAP1 [nucleoplasm]'
regulationReference	[RegulationReference:9641266] Negative regulation by 'FOXH1:DRAP1 [nucleoplasm]' Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1
releaseDate	2011-09-20
reviewed	[InstanceEdit:1529118] Peng, C, 2011-08-24 [InstanceEdit:2584311] Chen, Ye-Guang, 2012-11-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1591348] R-HSA-1225919.7
summation	[Summation:1225873] SMAD2 and SMAD3 do not bind DNA efficiently. They must inter... [Summation:1226030] As inferred from mouse, DRAP1 binds FOXH1 and inhibits activ...
(hasEvent)	[Pathway:1181150] Signaling by NODAL [Homo sapiens] [Pathway:1502540] Signaling by Activin [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776043] Update Tracker - [Reaction:1225919] Phospho R-SMAD(SMAD2,3):CO-SMAD(SMAD4):FOXH1 binds Activin Response Element - v78:[addSummation] [_UpdateTracker:9788200] Update Tracker - [Reaction:1225919] Phospho R-SMAD(SMAD2,3):CO-SMAD(SMAD4):FOXH1 binds Activin Response Element - v43:[addLiteratureReference, modifyText]
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No pathways have been reviewed or authored by Phospho R-SMAD(SMAD2,3):CO-SMAD(SMAD4):FOXH1 binds Activin Response Element (1225919)