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Details on Person Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL

Class:Id	Reaction:1225894
_displayName	Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL
_doRelease	TRUE
_timestamp	2014-02-03 18:45:55
authored	[InstanceEdit:1181143] May, B, 2011-01-23
catalystActivity	[CatalystActivity:1225901] protein serine/threonine kinase activity of NODAL:ACVR1C:ACVR2B:EGF-CFC [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:1225868] May, B, 2011-03-03
edited	[InstanceEdit:1181143] May, B, 2011-01-23
inferredFrom	[Reaction:1181149] ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin [Homo sapiens]
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:1225912] NODAL:ACVR1C:ACVR2B:EGF-CFC [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1181296] ALK7, a receptor for nodal, is dispensable for embryogenesis and left-right patterning in the mouse [LiteratureReference:1181094] The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development [LiteratureReference:1549506] Nodal and activin receptor-like kinase 7 induce apoptosis in human breast cancer cell lines: Role of caspase 3 [LiteratureReference:1225998] Nodal Signals through Activin Receptor-Like Kinase 7 to Inhibit Trophoblast Migration and Invasion Implication in the Pathogenesis of Preeclampsia
modified	[InstanceEdit:1225996] May, B, 2011-03-04 [InstanceEdit:1498828] May, B, 2011-08-18 [InstanceEdit:1529117] May, B, 2011-08-24 [InstanceEdit:1549505] May, B, 2011-08-28 [InstanceEdit:1549508] May, B, 2011-08-28 [InstanceEdit:2473229] May, B, 2012-09-21 [InstanceEdit:5251385] May, B, 2014-02-03 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:1225915] NODAL:p-ACVR1C:ACVR2B:EGF-CFC [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1181155] The NODAL Receptor binds NODAL ligands [Homo sapiens] [Reaction:1181152] Cleavage of NODAL proprotein [Homo sapiens] [BlackBoxEvent:452338] Expression of TDGF1 (CRIPTO) [Homo sapiens]
releaseDate	2011-09-20
reviewed	[InstanceEdit:1529118] Peng, C, 2011-08-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1591346] R-HSA-1225894.2
summation	[Summation:1225997] As inferred from the response of the activin receptor to act...
(hasEvent)	[Pathway:1181150] Signaling by NODAL [Homo sapiens]
(precedingEvent)	[Reaction:1181355] Phosphorylation of R-SMAD2/3 by NODAL receptor [Homo sapiens]
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