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Details on Person Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways

Class:IdLiteratureReference:1225829
_displayNameGefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
_timestamp2011-03-02 19:21:30
author[Person:416553] Sordella, R
[Person:390170] Bell, DW
[Person:390192] Haber, DA
[Person:416598] Settleman, J
created[InstanceEdit:1225830] Orlic-Milacic, Marija, 2011-03-02
journalScience
pages1163-7
pubMedIdentifier15284455
titleGefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
volume305
year2004
(literatureReference)[Summation:1181246] Signaling by EGFR is frequently activated in cancer through ...
[Summation:1225942] SOS is the guanine nucleotide exchange factor (GEF) for Ras....
[Summation:1247551] Recruitment of GRB2:SOS1 complex by SHC1 bound to phosphoryl...
[Reaction:1169421] Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers [Homo sapiens]
[Reaction:1225947] Binding of SHC1 to p-6Y-EGFR mutants [Homo sapiens]
[Reaction:1225949] Binding of CBL to ligand-responsive p-6Y-EGFR mutants [Homo sapiens]
[Reaction:1225950] Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants [Homo sapiens]
[Reaction:1225951] SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants) [Homo sapiens]
[Reaction:1225957] SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants) [Homo sapiens]
[Reaction:1226012] Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants [Homo sapiens]
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