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Details on Person Iron is reduced and separates from mycobactin

Class:Id	Reaction:1222399
_displayName	Iron is reduced and separates from mycobactin
_doRelease	TRUE
_timestamp	2014-07-14 09:05:20
authored	[InstanceEdit:1222281] Stephan, R, 2011-01-10
catalystActivity	[CatalystActivity:1222683] FMN reductase (NADPH) activity of IrtAB:Rv2895c [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:1222482] Jassal, B, 2011-02-28
disease	[Disease:1660556] tuberculosis
edited	[InstanceEdit:1222482] Jassal, B, 2011-02-28
inferredFrom	[Reaction:1222667] Iron is reduced and separates from enterobactin [Escherichia coli]
input	[Complex:5607579] Mycobactin:Fe3+ [cytosol] [Complex:5607579] Mycobactin:Fe3+ [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:29364] NADPH [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1222592] Mechanistic insights into a novel exporter-importer system of Mycobacterium tuberculosis unravel its role in trafficking of iron
modified	[InstanceEdit:1641501] Jassal, B, 2011-10-11 [InstanceEdit:1963552] Jassal, B, 2011-11-03 [InstanceEdit:1996247] Matthews, L, 2011-11-18 [InstanceEdit:2018636] Jassal, Bijay, 2011-11-23 [InstanceEdit:2103116] Jassal, B, 2012-02-08 [InstanceEdit:2105559] Jassal, B, 2012-02-10 [InstanceEdit:2143452] Jassal, Bijay, 2012-02-25 [InstanceEdit:2201373] Jassal, B, 2012-04-20 [InstanceEdit:2213260] Jassal, B, 2012-04-30 [InstanceEdit:2220948] Jassal, Bijay, 2012-05-03 [InstanceEdit:2592062] D'Eustachio, P, 2012-11-19 [InstanceEdit:3508881] Jassal, B, 2013-05-20 [InstanceEdit:5255454] D'Eustachio, Peter, 2014-02-06 [InstanceEdit:5607580] Jassal, Bijay, 2014-07-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Iron is reduced and separates from mycobactin
output	[SimpleEntity:71067] Fe2+ [cytosol] [SimpleEntity:71067] Fe2+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:1222609] Mycobactin [cytosol] [SimpleEntity:1222609] Mycobactin [cytosol] [SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:29366] NADP+ [cytosol]
precedingEvent	[Reaction:1222597] Loaded mycobactin gets imported [Homo sapiens] [Reaction:1222325] Carboxymycobactin and mycobactin exchange their iron load [Homo sapiens]
relatedSpecies	[Species:176806] Mycobacterium tuberculosis
releaseDate	2012-06-12
reviewed	[InstanceEdit:2213261] Warner, D, 2012-04-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2295293] R-HSA-1222399.2
summation	[Summation:1222752] The IrtA transporter has a flavin reductase domain very much...
(hasEvent)	[Pathway:1222449] Mtb iron assimilation by chelation [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9786300] Update Tracker - [Reaction:1222399] Iron is reduced and separates from mycobactin - v50:[add_removeInput] [_UpdateTracker:9788267] Update Tracker - [Reaction:1222399] Iron is reduced and separates from mycobactin - v43:[addOutput]
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