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Details on Person UniProt:Q9VY99-2 Nna1
| Class:Id | ReferenceIsoform:1220662 |
|---|---|
| _chainChangeLog | chain:1-1201 added on Fri February 6 2015 |
| _displayName | UniProt:Q9VY99-2 Nna1 |
| _timestamp | 2025-08-15 22:18:20 |
| chain | chain:1-1201 |
| checksum | AC52F081324B879B |
| comment | FUNCTION Metallocarboxypeptidase.COFACTOR Binds 1 zinc ion per subunit.SUBCELLULAR LOCATION In larvae, highly expressed in the brain, optic lobes, and ventral ganglia.DEVELOPMENTAL STAGE Expressed in larvae and adults.DISRUPTION PHENOTYPE Semilethal phenotype: females survive, while males die. Most male flies die between the late second instar larval stage and early pupal stage. Mutant males that survive to produce pupal cases initiate morphogenesis but die before head eversion. Almost all male flies that survive past head eversion do complete morphogenesis, and then eclose as 'escaper' males. Escapers display a range of phenotypes that mirror the disease pathology observed in pcd mice, including retinal degeneration.SIMILARITY Belongs to the peptidase M14 family. |
| created | [InstanceEdit:1220657] Yung, CK |
| description | recommendedName: fullName evidence="7"Cytosolic carboxypeptidase Nna1 ecNumber: 3.4.17.- alternativeName: Nervous system nuclear protein induced by axotomy protein 1 homolog |
| geneName | Nna1 NnaD CG44533 |
| identifier | Q9VY99 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Carboxypeptidase Hydrolase Metal-binding Metalloprotease Mitochondrion Protease Reference proteome Zinc |
| modified | [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | Nna1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | NNAD_DROME A8JUW0 C7LAD7 Q86B56 Q8T9D7 |
| sequenceLength | 1201 |
| species | [Species:56210] Drosophila melanogaster |
| variantIdentifier | Q9VY99-2 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9VY99-2 Nna1 (1220662)
