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Details on Person UniProt:Q0A2G1 NP
| Class:Id | ReferenceGeneProduct:1220659 |
|---|---|
| _chainChangeLog | chain:1-498 added on Fri February 6 2015 |
| _displayName | UniProt:Q0A2G1 NP |
| _timestamp | 2023-11-03 15:19:32 |
| chain | chain:1-498 |
| checksum | B126398E5445F96B |
| comment | FUNCTION Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway. Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.SUBUNIT Homomultimerizes to form the nucleocapsid. May bind host exportin-1/XPO1. Binds to viral genomic RNA. Protein-RNA contacts are mediated by a combination of electrostatic interactions between positively charged residues and the phosphate backbone and planar interactions between aromatic side chains and bases.SUBCELLULAR LOCATION Late in virus-infected cells, may be cleaved from a 56-kDa protein to a 53-kDa protein by a cellular caspase. This cleavage might be a marker for the onset of apoptosis in infected cells or have a specific function in virus host interaction.SIMILARITY Belongs to the influenza viruses nucleoprotein family. |
| created | [InstanceEdit:1220657] Yung, CK |
| description | recommendedName: fullName evidence="1"Nucleoprotein alternativeName: fullName evidence="1"Nucleocapsid protein shortName evidence="1"Protein N |
| geneName | NP |
| identifier | Q0A2G1 |
| isSequenceChanged | FALSE |
| keyword | Capsid protein Helical capsid protein Host nucleus Host-virus interaction Ribonucleoprotein RNA-binding Viral nucleoprotein Viral penetration into host nucleus Virion Virus entry into host cell |
| modified | [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2455454] Weiser, JD [InstanceEdit:4341137] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9015733] Weiser, JD [InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01 [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | NP |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | NCAP_I83A4 |
| sequenceLength | 498 |
| species | [Species:9031716] Influenza A virus |
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No pathways have been reviewed or authored by UniProt:Q0A2G1 NP (1220659)
