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Details on Person Spontaneous dimerization of ligand-responsive EGFR mutants

Class:Id	Reaction:1220614
_displayName	Spontaneous dimerization of ligand-responsive EGFR mutants
_doRelease	TRUE
_timestamp	2014-11-12 21:13:57
authored	[InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:1220609] Orlic-Milacic, Marija, 2011-02-22
disease	[Disease:1500689] cancer
edited	[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07
entityFunctionalStatus	[EntityFunctionalStatus:5637721] gain_of_function of Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane]
input	[DefinedSet:1218825] Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] [Homo sapiens] [DefinedSet:1218825] Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1181011] An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor [LiteratureReference:1181018] Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants [LiteratureReference:1169414] Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity [LiteratureReference:1181025] The juxtamembrane region of the EGF receptor functions as an activation domain
modified	[InstanceEdit:1235098] Orlic-Milacic, Marija, 2011-03-23 [InstanceEdit:1236390] Orlic-Milacic, Marija, 2011-03-25 [InstanceEdit:1246139] Orlic-Milacic, Marija, 2011-04-01 [InstanceEdit:1247850] Orlic-Milacic, Marija, 2011-04-07 [InstanceEdit:1247851] Orlic-Milacic, Marija, 2011-04-07 [InstanceEdit:1500854] Orlic-Milacic, Marija, 2011-08-22 [InstanceEdit:1643704] Orlic-Milacic, Marija, 2011-10-11 [InstanceEdit:1660495] Orlic-Milacic, Marija, 2011-10-13 [InstanceEdit:1667628] Orlic-Milacic, Marija, 2011-10-14 [InstanceEdit:1979631] Orlic-Milacic, Marija, 2011-11-08 [InstanceEdit:1990842] Orlic-Milacic, Marija, 2011-11-14 [InstanceEdit:1990860] Orlic-Milacic, Marija, 2011-11-14 [InstanceEdit:1998737] Orlic-Milacic, Marija, 2011-11-19 [InstanceEdit:2023591] Matthews, L, 2011-12-09 [InstanceEdit:5637816] Orlic-Milacic, Marija, 2014-11-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Spontaneous dimerization of ligand-responsive EGFR mutants
output	[Complex:1500849] Ligand-responsive EGFR mutants dimer [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:1218833] Binding of ligand-responsive EGFR mutants to chaperoning proteins HSP90 and CDC37 [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016546] R-HSA-1220614.2
summation	[Summation:1173215] EGFR ligand-responsive mutants dimerize spontaneously, witho...
(hasEvent)	[Pathway:1169434] Signaling by constitutively active EGFR kinase domain mutants [Homo sapiens] [Pathway:1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants [Homo sapiens]
(precedingEvent)	[Reaction:1169421] Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers [Homo sapiens] [Reaction:1220610] Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants [Homo sapiens]
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