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Details on Person Binding of EGF to ligand-responsive EGFR mutants
Class:Id Reaction:1220612 _displayName Binding of EGF to ligand-responsive EGFR mutants _doRelease TRUE _timestamp 2019-02-22 18:13:28 authored [InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04 compartment [Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region created [InstanceEdit:1220609] Orlic-Milacic, Marija, 2011-02-22 disease [Disease:1500689] cancer edited [InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07 entityFunctionalStatus [EntityFunctionalStatus:5637721] gain_of_function of Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] input [DefinedSet:1218825] Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:179863] EGF [extracellular region] [Homo sapiens] isChimeric FALSE literatureReference [LiteratureReference:1181018] Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants [LiteratureReference:2008165] Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain modified [InstanceEdit:1235099] Orlic-Milacic, Marija, 2011-03-23 [InstanceEdit:1236373] Orlic-Milacic, Marija, 2011-03-24 [InstanceEdit:1236390] Orlic-Milacic, Marija, 2011-03-25 [InstanceEdit:1246112] Orlic-Milacic, Marija, 2011-04-01 [InstanceEdit:1247850] Orlic-Milacic, Marija, 2011-04-07 [InstanceEdit:1247851] Orlic-Milacic, Marija, 2011-04-07 [InstanceEdit:1643690] Orlic-Milacic, Marija, 2011-10-11 [InstanceEdit:1660495] Orlic-Milacic, Marija, 2011-10-13 [InstanceEdit:1678900] Orlic-Milacic, Marija, 2011-10-19 [InstanceEdit:1979631] Orlic-Milacic, Marija, 2011-11-08 [InstanceEdit:1990842] Orlic-Milacic, Marija, 2011-11-14 [InstanceEdit:1990860] Orlic-Milacic, Marija, 2011-11-14 [InstanceEdit:1998737] Orlic-Milacic, Marija, 2011-11-19 [InstanceEdit:2008188] Orlic-Milacic, Marija, 2011-11-22 [InstanceEdit:2023591] Matthews, L, 2011-12-09 [InstanceEdit:5637816] Orlic-Milacic, Marija, 2014-11-12 [InstanceEdit:9628442] Orlic-Milacic, Marija, 2018-11-08 [InstanceEdit:9634807] Orlic-Milacic, Marija, 2019-01-15 [InstanceEdit:9637996] Orlic-Milacic, Marija, 2019-02-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name Binding of EGF to ligand-responsive EGFR mutants normalReaction
output [DefinedSet:1220578] EGF:Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane] [Homo sapiens] precedingEvent
releaseDate 2011-12-06 reviewed [InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:2016377] R-HSA-1220612.4 summation [Summation:1236387] Ligand-responsive EGFR mutants are able to bind EGF and exhi... (hasEvent) [Pathway:1169434] Signaling by constitutively active EGFR kinase domain mutants [Homo sapiens] [Pathway:1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants [Homo sapiens] (precedingEvent) [Reaction:1220613] EGF-induced dimerization of ligand-responsive EGFR mutants [Homo sapiens]
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No pathways have been reviewed or authored by Binding of EGF to ligand-responsive EGFR mutants (1220612)
