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Details on Person HSP90 is inactivated by binding to benzaquinoid ansamycins

Class:Id	Reaction:1218824
_displayName	HSP90 is inactivated by binding to benzaquinoid ansamycins
_doRelease	TRUE
_timestamp	2011-11-23 11:11:55
authored	[InstanceEdit:1972359] Orlic-Milacic, M, 2011-11-04
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1218828] Orlic-Milacic, Marija, 2011-02-17
disease	[Disease:1500689] cancer
edited	[InstanceEdit:1972360] D'Eustachio, P, 2011-11-07 [InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:1990858] Jassal, B, 2011-11-07 [InstanceEdit:1990853] Wu, G, 2011-11-07
input	[DefinedSet:1217511] Benzoquinoid ansamycins [cytosol] [Complex:1221657] HSP90 [cytosol] [Homo sapiens] [DefinedSet:1217511] Benzoquinoid ansamycins [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1218826] Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent
modified	[InstanceEdit:1220607] Orlic-Milacic, Marija, 2011-02-22 [InstanceEdit:1221662] Orlic-Milacic, Marija, 2011-02-25 [InstanceEdit:1236376] Orlic-Milacic, Marija, 2011-03-24 [InstanceEdit:1247554] Orlic-Milacic, Marija, 2011-04-01 [InstanceEdit:1247610] Orlic-Milacic, Marija, 2011-04-04 [InstanceEdit:1643697] Orlic-Milacic, Marija, 2011-10-11 [InstanceEdit:1660495] Orlic-Milacic, Marija, 2011-10-13 [InstanceEdit:1667623] Orlic-Milacic, Marija, 2011-10-14 [InstanceEdit:1979631] Orlic-Milacic, Marija, 2011-11-08 [InstanceEdit:1990842] Orlic-Milacic, Marija, 2011-11-14 [InstanceEdit:1990860] Orlic-Milacic, Marija, 2011-11-14 [InstanceEdit:2023591] Matthews, L, 2011-12-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	HSP90 is inactivated by binding to benzaquinoid ansamycins
output	[Complex:1218829] HSP90:Benzoquinoid ansamycins [cytosol] [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1990843] Greulich, H, 2011-11-15 [InstanceEdit:1990844] Savas, S, 2011-11-15
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016431] R-HSA-1218824.2
summation	[Summation:1218831] Benzoquinoid ansamycins (geldanamycin, herbimycin, and gelda...
(hasEvent)	[Pathway:1169434] Signaling by constitutively active EGFR kinase domain mutants [Homo sapiens] [Pathway:1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants [Homo sapiens] [Pathway:5637810] Constitutive Signaling by EGFRvIII [Homo sapiens]
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No pathways have been reviewed or authored by HSP90 is inactivated by binding to benzaquinoid ansamycins (1218824)