Query author contributions in Reactome

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Details on Person Covalent EGFR tyrosine kinase inhibitors [cytosol]

Class:Id	DefinedSet:1216522
_displayName	Covalent EGFR tyrosine kinase inhibitors [cytosol]
_timestamp	2012-08-28 18:18:11
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1216529] Orlic-Milacic, Marija, 2011-02-15
disease	[Disease:1500689] cancer
hasMember	[DefinedSet:1216530] Irreversible EGFR-specific TKIs [cytosol] [ChemicalDrug:1216524] Pelitinib [cytosol] [ChemicalDrug:1227674] WZ4002 [cytosol] [DefinedSet:1216531] Irreversible anti-EGFRplus TKIs [cytosol] [ChemicalDrug:1216527] neratinib [cytosol] [ChemicalDrug:1227677] Canertinib [cytosol] [ChemicalDrug:1220577] Afatinib [cytosol]
modified	[InstanceEdit:1221661] Orlic-Milacic, Marija, 2011-02-25 [InstanceEdit:1246142] Orlic-Milacic, Marija, 2011-04-01 [InstanceEdit:1247347] Orlic-Milacic, Marija, 2011-04-01 [InstanceEdit:1500917] Orlic-Milacic, Marija, 2011-08-22 [InstanceEdit:1667319] Orlic-Milacic, Marija, 2011-10-14 [InstanceEdit:2457820] Orlic-Milacic, M, 2012-08-28
name	Covalent EGFR tyrosine kinase inhibitors Irreversible EGFR TKIs Irreversible anti-EGFR tyrosine kinase inhibitors
stableIdentifier	[StableIdentifier:2016821] R-ALL-1216522.1
(hasComponent)	[Complex:1220579] Resistant ligand-responsive EGFR mutants:Covalent EGFR TKIs [plasma membrane] [Homo sapiens] [Complex:1225979] EGF-like ligands:EGFR Dimer:Covalent EGFR TKIs [plasma membrane] [Homo sapiens]
(input)	[Reaction:1220611] Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors [Homo sapiens] [Reaction:1225978] Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9872127] Update Tracker - [DefinedSet:1216522] Covalent EGFR tyrosine kinase inhibitors [cytosol] - v41:[updateContainedMemberOrCandidate] [_UpdateTracker:9873023] Update Tracker - [DefinedSet:1216522] Covalent EGFR tyrosine kinase inhibitors [cytosol] - v42:[removeSpecies]
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No pathways have been reviewed or authored by Covalent EGFR tyrosine kinase inhibitors [cytosol] (1216522)