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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person Lapatinib [cytosol]

Class:IdChemicalDrug:1216521
_displayNameLapatinib [cytosol]
_timestamp2018-12-12 00:29:44
compartment[Compartment:70101] cytosol
created[InstanceEdit:1216529] Orlic-Milacic, Marija, 2011-02-15
crossReference[DatabaseIdentifier:9628095] ChEBI:49603
disease[Disease:1500689] cancer
modified[InstanceEdit:1220598] Orlic-Milacic, Marija, 2011-02-22
[InstanceEdit:1227903] Orlic-Milacic, Marija, 2011-03-10
[InstanceEdit:1227909] Orlic-Milacic, Marija, 2011-03-11
[InstanceEdit:1667319] Orlic-Milacic, Marija, 2011-10-14
[InstanceEdit:9016686] Orlic-Milacic, Marija, 2017-08-14
[InstanceEdit:9028147] Weiser, JD
[InstanceEdit:9616752] Shorser, Solomon, 2018-08-13
[InstanceEdit:9619953] Wu, G, 2018-09-19
[InstanceEdit:9627975] Wu, G, 2018-11-05
[InstanceEdit:9631716] Wu, G, 2018-12-12
nameLapatinib
GW572016
Tykerb
Reversible tyrosine kinase inhibitor lapatinib generic inhibits EGFR and ERBB2 (HER2)
referenceEntity[ReferenceTherapeutic:9016665] lapatinib [Guide to Pharmacology:5692]
stableIdentifier[StableIdentifier:2017846] R-ALL-1216521.2
(activeUnit)[NegativeRegulation:9649932] Negative regulation by 'Lapatinib:ERBB2 KD mutant heterodimers [plasma membrane]'
[NegativeRegulation:9665328] Negative regulation by 'ERBB2 KD mutants (trastuzumab sensitive):trastuzumab:ERBIN:HSP90:CDC37 [plasma membrane]'
(hasCandidate)[CandidateSet:9655019] afatinib,neratinib,osimertinib,(lapatinib,sapitinib) [cytosol]
[CandidateSet:9655148] (lapatinib) [cytosol]
[CandidateSet:9655270] afatinib,neratinib,osimertinib,(lapatinib) [cytosol]
(hasComponent)[Complex:9649880] Lapatinib:ERBB2 KD mutant heterodimers [plasma membrane] [Homo sapiens]
[Complex:9665145] ERBB2 KD mutants:lapatinib [plasma membrane] [Homo sapiens]
[Complex:9665938] ERBB2 TMD/JMD mutants (lapatinib):lapatinib [plasma membrane] [Homo sapiens]
(hasMember)[DefinedSet:1216525] Reversible anti-EGFRplus TKIs [cytosol]
[DefinedSet:1237431] afatinib, neratinib, lapatinib [cytosol] [Homo sapiens]
[DefinedSet:9652360] lapatinib, neratinib, afatinib, AZ5104, tesevatinib, canertinib, sapitinib, CP-724714, AEE78 [cytosol]
[DefinedSet:9655000] lapatinib,AEE788 [cytosol]
[DefinedSet:9655128] afatinib,lapatinib,neratinib,osimertinib,sapitinib [cytosol]
[CandidateSet:9655178] afatinib,lapatinib,neratinib,osimertinib,(sapitinib) [cytosol]
[DefinedSet:9655204] AEE788,afatinib,lapatinib,neratinib,osimertinib [cytosol] [Homo sapiens]
[DefinedSet:9655206] lapatinib,neratinib,osimertinib [cytosol]
[DefinedSet:9655239] lapatinib,tesevatinib [cytosol]
[DefinedSet:9655289] lapatinib,osimertinib [cytosol] [Homo sapiens]
List all 12 refering instances
(input)[FailedReaction:9650938] ERBB2 V842I does not bind lapatinib [Homo sapiens]
[FailedReaction:9665284] Resistant ERBB2 KD mutants do not bind lapatinib [Homo sapiens]
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No pathways have been reviewed or authored by Lapatinib [cytosol] (1216521)
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