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Details on Person Ligand-responsive EGFR mutants resistant to non-covalent TKIs [plasma membrane]

Class:Id	CandidateSet:1182967
_displayName	Ligand-responsive EGFR mutants resistant to non-covalent TKIs [plasma membrane]
_timestamp	2011-11-23 11:48:36
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1182968] Orlic-Milacic, Marija, 2011-02-09
disease	[Disease:1500689] cancer
hasCandidate	[EntityWithAccessionedSequence:1996322] EGFR D770_N771insNPG [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:1996317] EGFR N771_H773dup [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:1996326] EGFR A767_V769dup [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:1996325] EGFR K739_I744dup [plasma membrane] [Homo sapiens]
hasMember	[EntityWithAccessionedSequence:1181399] EGFR E746_A750del;T790M [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:1181386] EGFR L858R;T790M [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:1181387] Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors [LiteratureReference:1182969] The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
modified	[InstanceEdit:1217516] Orlic-Milacic, Marija, 2011-02-17 [InstanceEdit:1247347] Orlic-Milacic, Marija, 2011-04-01 [InstanceEdit:1247850] Orlic-Milacic, Marija, 2011-04-07 [InstanceEdit:1247851] Orlic-Milacic, Marija, 2011-04-07 [InstanceEdit:1667317] Orlic-Milacic, Marija, 2011-10-14 [InstanceEdit:1667629] Orlic-Milacic, Marija, 2011-10-14 [InstanceEdit:1678902] Orlic-Milacic, Marija, 2011-10-19 [InstanceEdit:1996378] Orlic-Milacic, Marija, 2011-11-19
name	Ligand-responsive EGFR mutants resistant to non-covalent TKIs
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2017854] R-HSA-1182967.1
(hasComponent)	[Complex:1220573] EGF:Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] [Homo sapiens] [Complex:1220581] Ligand-responsive EGFR mutants resistant to non-covalent TKIs:HSP90:CDC37 [plasma membrane] [Homo sapiens]
(hasMember)	[DefinedSet:1182966] Ligand-responsive EGFR mutants [plasma membrane] [Homo sapiens]
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No pathways have been reviewed or authored by Ligand-responsive EGFR mutants resistant to non-covalent TKIs [plasma membrane] (1182967)