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Details on Person EGFR E746_A750del [plasma membrane]

Class:Id	EntityWithAccessionedSequence:1181211
_displayName	EGFR E746_A750del [plasma membrane]
_timestamp	2018-10-29 16:51:44
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1181209] Orlic-Milacic, Marija, 2011-01-31
crossReference	[DatabaseIdentifier:1655478] COSMIC:COSV51765119 [DatabaseIdentifier:1655482] COSMIC:COSM12980 [DatabaseIdentifier:1655485] COSMIC:COSV51765066
disease	[Disease:1500689] cancer [Disease:1500699] lung cancer [Disease:1247848] non-small cell lung carcinoma [Disease:1655480] salivary gland cancer [Disease:1655479] parotid gland cancer [Disease:1655470] thyroid cancer [Disease:1655467] papillary thyroid carcinoma [Disease:1500575] ovarian cancer [Disease:1248679] head and neck squamous cell carcinoma [Disease:1655483] renal clear cell carcinoma [Disease:1655484] kidney cancer [Disease:1500576] breast cancer
endCoordinate	1210
hasModifiedResidue	[FragmentDeletionModification:9626687] Deletion of residues 746 to 750
literatureReference	[LiteratureReference:1181035] Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
modified	[InstanceEdit:1181239] Orlic-Milacic, Marija, 2011-02-01 [InstanceEdit:1182974] Orlic-Milacic, Marija, 2011-02-09 [InstanceEdit:1247850] Orlic-Milacic, Marija, 2011-04-07 [InstanceEdit:1248671] Orlic-Milacic, Marija, 2011-04-11 [InstanceEdit:1655477] Orlic-Milacic, Marija, 2011-10-12 [InstanceEdit:1655481] Orlic-Milacic, Marija, 2011-10-12 [InstanceEdit:3662293] Orlic-Milacic, M, 2013-06-06 [InstanceEdit:9626688] Orlic-Milacic, Marija, 2018-10-29
name	EGFR E746_A750del Epidermal Growth Factor Receptor E746_A750del EGFR Glu746_Ala750del
referenceEntity	[ReferenceGeneProduct:54208] UniProt:P00533 EGFR [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2017111] R-HSA-1181211.2
startCoordinate	25
(hasMember)	[CandidateSet:1176052] Ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane] [Homo sapiens] [CandidateSet:1182964] EGFR L747_A750del spanning mutants [plasma membrane] [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9888541] Update Tracker - [EntityWithAccessionedSequence:1181211] EGFR E746_A750del [plasma membrane] - v46:[modifyName] [_UpdateTracker:9899774] Update Tracker - [EntityWithAccessionedSequence:1181211] EGFR E746_A750del [plasma membrane] - v67:[add_removeHasModifiedResidue]
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No pathways have been reviewed or authored by EGFR E746_A750del [plasma membrane] (1181211)