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Details on Person Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B

Class:Id	Reaction:1181153
_displayName	Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B
_doRelease	TRUE
_timestamp	2023-08-21 15:21:14
authored	[InstanceEdit:1181143] May, B, 2011-01-23
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:1181146] May, B, 2011-01-27
edited	[InstanceEdit:1181143] May, B, 2011-01-23
input	[EntityWithAccessionedSequence:205867] ACVR1B [plasma membrane] [Homo sapiens] [DefinedSet:1181136] ACVR2A,B [plasma membrane] [Homo sapiens] [DefinedSet:2470494] Activin A,AB,B [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:205867] ACVR1B [plasma membrane] [Homo sapiens] [DefinedSet:1181136] ACVR2A,B [plasma membrane] [Homo sapiens]
internalReviewed	[InstanceEdit:9842171] Orlic-Milacic, Marija, 2023-08-21
isChimeric	FALSE
literatureReference	[LiteratureReference:1549497] Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin [LiteratureReference:1181098] Truncated activin type I receptor Alk4 isoforms are dominant negative receptors inhibiting activin signaling [LiteratureReference:1181075] Activation of signalling by the activin receptor complex [LiteratureReference:1549494] Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation
modified	[InstanceEdit:1225996] May, B, 2011-03-04 [InstanceEdit:1549501] May, B, 2011-08-28 [InstanceEdit:2470509] May, B, 2012-09-18 [InstanceEdit:2559592] May, B, 2012-11-02 [InstanceEdit:2584313] May, B, 2012-11-14 [InstanceEdit:5251385] May, B, 2014-02-03 [InstanceEdit:8858361] Jupe, Steve, 2016-02-18 [InstanceEdit:9717243] May, Bruce, 2021-03-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9839333] Tiwari, Krishna, 2023-07-05 [InstanceEdit:9840925] Tiwari, Krishna, 2023-08-01 [InstanceEdit:9842172] Orlic-Milacic, Marija, 2023-08-21
name	Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B
output	[Complex:1549493] Activin A,AB,B:ACVR2A,B:ACVR1B [plasma membrane] [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[NegativeRegulation:9839345] Negative regulation by 'INHIBIN-A:TGFBR3:ACVR2A [plasma membrane]'
regulationReference	[RegulationReference:9840924] Negative regulation by 'InhibinA:TGFBR3:ACVR2A' Inhibin is an antagonist of bone morphogenetic protein signaling
releaseDate	2012-12-04
reviewed	[InstanceEdit:2584311] Chen, Ye-Guang, 2012-11-14
reviewStatus	[ReviewStatus:9821385] four stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:3200516] R-HSA-1181153.5
structureModified	[InstanceEdit:9839333] Tiwari, Krishna, 2023-07-05
summation	[Summation:1225984] Activin binds the Activin receptor composed of a type II rec...
(hasEvent)	[Pathway:1502540] Signaling by Activin [Homo sapiens]
(precedingEvent)	[Reaction:1181149] ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9842246] Update Tracker - [Reaction:1181153] Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B - v86:[addRegulator, modifyText]
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No pathways have been reviewed or authored by Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (1181153)