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Details on Person Cleavage of Nodal proprotein

Class:Id	Reaction:1181148
_displayName	Cleavage of Nodal proprotein
_doRelease	TRUE
_timestamp	2014-02-03 18:45:09
authored	[InstanceEdit:1181143] May, B, 2011-01-23
catalystActivity	[CatalystActivity:1181157] serine-type endopeptidase activity of Furin and Pace4 [extracellular region]
catalystActivityReference	[CatalystActivityReference:9643598] serine-type endopeptidase activity of Furin and Pace4 [extracellular region] Extraembryonic proteases regulate Nodal signalling during gastrulation
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:1181146] May, B, 2011-01-27
edited	[InstanceEdit:1181143] May, B, 2011-01-23
input	[EntityWithAccessionedSequence:1181122] Nodal (proprotein) [extracellular region] [Mus musculus]
isChimeric	FALSE
literatureReference	[LiteratureReference:1181091] Extraembryonic proteases regulate Nodal signalling during gastrulation [LiteratureReference:1181089] Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases [LiteratureReference:1181096] Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation
modified	[InstanceEdit:1498828] May, B, 2011-08-18 [InstanceEdit:1529117] May, B, 2011-08-24 [InstanceEdit:5251385] May, B, 2014-02-03 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Cleavage of Nodal proprotein
output	[EntityWithAccessionedSequence:1181116] Nodal [extracellular region] [Mus musculus]
releaseDate	2011-09-20
reviewed	[InstanceEdit:1529118] Peng, C, 2011-08-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:1591396] R-MMU-1181148.3
summation	[Summation:1181068] Nodal proprotein can be cleaved extracellularly by either Fu...
(inferredFrom)	[Reaction:1181152] Cleavage of NODAL proprotein [Homo sapiens]
(precedingEvent)	[Reaction:1181347] Lefty binds Nodal [Mus musculus] [Reaction:1225898] The Nodal Receptor binds Nodal ligands [Mus musculus]
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No pathways have been reviewed or authored by Cleavage of Nodal proprotein (1181148)