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Details on Person Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

Class:IdLiteratureReference:1181035
_displayNameActivating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
_timestamp2011-01-27 17:34:07
author[Person:375194] Lynch, TJ
[Person:390170] Bell, DW
[Person:416553] Sordella, R
[Person:1181033] Gurubhagavatula, S
[Person:1181029] Okimoto, RA
[Person:1181039] Brannigan, BW
[Person:1181036] Harris, PL
[Person:1181030] Haserlat, SM
[Person:1181038] Supko, JG
[Person:1181031] Haluska, FG
[Person:1181032] Louis, DN
[Person:1181034] Christiani, DC
[Person:416598] Settleman, J
[Person:390192] Haber, DA
created[InstanceEdit:1181037] Orlic-Milacic, Marija, 2011-01-27
journalN Engl J Med
pages2129-39
pubMedIdentifier15118073
titleActivating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
volume350
year2004
(literatureReference)[EntityWithAccessionedSequence:1177542] EGFR L861Q [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:1181211] EGFR E746_A750del [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:1181399] EGFR E746_A750del;T790M [plasma membrane] [Homo sapiens]
[CandidateSet:1182964] EGFR L747_A750del spanning mutants [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:1228010] EGFR L747_P753delinsS [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:1228038] p-6Y-EGFR L747_P753delinsS [plasma membrane] [Homo sapiens]
[Summation:1181055] L861Q, a substitution of leucine 861 with glutamine, is a do...
[Summation:1181238] Most EGFR exon 19 deletions found in NSCLCs span LREA amino ...
[Summation:1181246] Signaling by EGFR is frequently activated in cancer through ...
[Pathway:1169434] Signaling by constitutively active EGFR kinase domain mutants [Homo sapiens]
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No pathways have been reviewed or authored by Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib (1181035)