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Details on Person p-6Y-EGFR L861Q [plasma membrane]

Class:Id	EntityWithAccessionedSequence:1177541
_displayName	p-6Y-EGFR L861Q [plasma membrane]
_timestamp	2013-06-06 16:42:26
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:1177539] Orlic-Milacic, Marija, 2011-01-25
disease	[Disease:1247848] non-small cell lung carcinoma
endCoordinate	1210
hasModifiedResidue	[ModifiedResidue:179797] O4'-phospho-L-tyrosine at 1092 [ModifiedResidue:179844] O4'-phospho-L-tyrosine at 1172 [ModifiedResidue:179872] O4'-phospho-L-tyrosine at 1197 [ModifiedResidue:179834] O4'-phospho-L-tyrosine at 1110 [ModifiedResidue:180321] O4'-phospho-L-tyrosine at 1016 [ModifiedResidue:182927] O4'-phospho-L-tyrosine at 1069 [ReplacedResidue:1177540] L-leucine 861 replaced with L-glutamine
literatureReference	[LiteratureReference:1169414] Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity
modified	[InstanceEdit:1225864] Orlic-Milacic, Marija, 2011-03-02 [InstanceEdit:1247850] Orlic-Milacic, Marija, 2011-04-07 [InstanceEdit:1248671] Orlic-Milacic, Marija, 2011-04-11 [InstanceEdit:3662293] Orlic-Milacic, M, 2013-06-06
name	p-6Y-EGFR L861Q Phosphorylated Epidermal Growth Factor Receptor L861Q p-6Y-EGFR Leu861Gln
referenceEntity	[ReferenceGeneProduct:54208] UniProt:P00533 EGFR [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016818] R-HSA-1177541.1
startCoordinate	25
(hasCandidate)	[CandidateSet:1182977] Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9888487] Update Tracker - [EntityWithAccessionedSequence:1177541] p-6Y-EGFR L861Q [plasma membrane] - v46:[modifyName]
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No pathways have been reviewed or authored by p-6Y-EGFR L861Q [plasma membrane] (1177541)