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Details on Person EGFR ligand-responsive mutants dimerize spontaneously, witho...

Class:IdSummation:1173215
_displayNameEGFR ligand-responsive mutants dimerize spontaneously, witho...
_timestamp2011-11-22 00:13:41
created[InstanceEdit:1173214] Orlic-Milacic, Marija, 2011-01-21
literatureReference[LiteratureReference:1181011] An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
[LiteratureReference:1181018] Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants
[LiteratureReference:1169414] Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity
[LiteratureReference:1181025] The juxtamembrane region of the EGF receptor functions as an activation domain
modified[InstanceEdit:1181199] Orlic-Milacic, Marija, 2011-01-28
[InstanceEdit:1236390] Orlic-Milacic, Marija, 2011-03-25
[InstanceEdit:1247607] Orlic-Milacic, Marija, 2011-04-04
[InstanceEdit:2008188] Orlic-Milacic, Marija, 2011-11-22
textEGFR ligand-responsive mutants dimerize spontaneously, without ligand binding, although ligand binding ability is preserved. This was experimentally demonstrated for EFGR L858R mutant and is presumed to happen in other constitutively active EGFR kinase domain mutants and EGFR extracellular domain point mutants.
(summation)[Reaction:1220614] Spontaneous dimerization of ligand-responsive EGFR mutants [Homo sapiens]
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