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Query author contributions in Reactome

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Details on Person EGFR L858R [plasma membrane]

Class:IdEntityWithAccessionedSequence:1173212
_displayNameEGFR L858R [plasma membrane]
_timestamp2013-06-06 16:42:21
compartment[Compartment:876] plasma membrane
created[InstanceEdit:1173208] Orlic-Milacic, Marija, 2011-01-21
crossReference[DatabaseIdentifier:1655469] COSMIC:COSV51765161
[DatabaseIdentifier:1655471] COSMIC:COSM12979
disease[Disease:1500689] cancer
[Disease:1500699] lung cancer
[Disease:1247848] non-small cell lung carcinoma
[Disease:1655468] thymus cancer
[Disease:1655472] thymoma
[Disease:1655470] thyroid cancer
[Disease:1655467] papillary thyroid carcinoma
[Disease:1500687] stomach cancer
[Disease:1500576] breast cancer
[Disease:1500575] ovarian cancer
[Disease:1655473] malignant peritoneal mesothelioma
endCoordinate1210
hasModifiedResidue[ReplacedResidue:1173209] L-leucine 858 replaced with L-arginine
literatureReference[LiteratureReference:1169414] Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity
[LiteratureReference:1181048] EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
modified[InstanceEdit:1181057] Orlic-Milacic, Marija, 2011-01-27
[InstanceEdit:1181158] Orlic-Milacic, Marija, 2011-01-28
[InstanceEdit:1181383] Orlic-Milacic, Marija, 2011-02-07
[InstanceEdit:1247850] Orlic-Milacic, Marija, 2011-04-07
[InstanceEdit:1248671] Orlic-Milacic, Marija, 2011-04-11
[InstanceEdit:1655466] Orlic-Milacic, Marija, 2011-10-12
[InstanceEdit:3662293] Orlic-Milacic, M, 2013-06-06
nameEGFR L858R
Epidermal Growth Factor Receptor L858R
EGFR Leu858Arg
referenceEntity[ReferenceGeneProduct:54208] UniProt:P00533 EGFR [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2017380] R-HSA-1173212.1
startCoordinate25
summation[Summation:1181056] L858R, a substitution of leucine 858 with arginine, accounts...
(hasMember)[CandidateSet:1176052] Ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane] [Homo sapiens]
(updatedInstance)[_UpdateTracker:9888372] Update Tracker - [EntityWithAccessionedSequence:1173212] EGFR L858R [plasma membrane] - v46:[modifyName]
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No pathways have been reviewed or authored by EGFR L858R [plasma membrane] (1173212)