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Details on Person Rasgrp1 and Rasgrp3 are recruited to the membrane and phosphorylated

Class:IdBlackBoxEvent:1169494
_displayNameRasgrp1 and Rasgrp3 are recruited to the membrane and phosphorylated
_doReleaseTRUE
_timestamp2012-03-01 11:24:26
authored[InstanceEdit:1169098] May, B, 2011-01-11
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:1169459] May, B, 2011-01-19
edited[InstanceEdit:1169098] May, B, 2011-01-11
input[SimpleEntity:112275] DAGs [plasma membrane]
[SimpleEntity:113592] ATP [cytosol]
[DefinedSet:1169599] Rasgrp1,3 [cytosol] [Mus musculus]
isChimericFALSE
literatureReference[LiteratureReference:1169518] RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling
[LiteratureReference:1169516] Differential membrane binding and diacylglycerol recognition by C1 domains of RasGRPs
[LiteratureReference:1169531] Regulation of RasGRP1 by B cell antigen receptor requires cooperativity between three domains controlling translocation to the plasma membrane
modified[InstanceEdit:1977928] May, B, 2011-11-08
[InstanceEdit:2010554] May, B, 2011-11-22
[InstanceEdit:2108989] May, B, 2012-02-11
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameRasgrp1 and Rasgrp3 are recruited to the membrane and phosphorylated
output[SimpleEntity:29370] ADP [cytosol]
[Complex:1169551] p-Rasgrp1,3:DAG [plasma membrane] [Mus musculus]
releaseDate2012-03-13
reviewed[InstanceEdit:2108988] Wienands, J, 2012-02-11
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48892] Mus musculus
stableIdentifier[StableIdentifier:2158188] R-MMU-1169494.2
summation[Summation:1169572] In mouse B cells both Rasgrp1 and Rasgrp3 are activated by b...
(inferredFrom)[BlackBoxEvent:1168374] RasGRP1 and RasGRP3 binds diacylglycerol and is phosphorylated [Homo sapiens]
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