Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person EGFR G719S [plasma membrane]

Class:IdEntityWithAccessionedSequence:1169418
_displayNameEGFR G719S [plasma membrane]
_timestamp2013-06-06 16:42:21
compartment[Compartment:876] plasma membrane
created[InstanceEdit:1169427] Orlic-Milacic, Marija, 2011-01-18
crossReference[DatabaseIdentifier:1655464] COSMIC:COSV51767289
[DatabaseIdentifier:1655461] COSMIC:COSM13983
disease[Disease:1247848] non-small cell lung carcinoma
[Disease:1500699] lung cancer
[Disease:1500689] cancer
[Disease:1248674] large intestine cancer
endCoordinate1210
hasModifiedResidue[ReplacedResidue:1169422] glycine 719 replaced with L-serine
literatureReference[LiteratureReference:1169414] Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity
modified[InstanceEdit:1177535] Orlic-Milacic, Marija, 2011-01-25
[InstanceEdit:1181057] Orlic-Milacic, Marija, 2011-01-27
[InstanceEdit:1182975] Orlic-Milacic, Marija, 2011-02-09
[InstanceEdit:1247850] Orlic-Milacic, Marija, 2011-04-07
[InstanceEdit:1248671] Orlic-Milacic, Marija, 2011-04-11
[InstanceEdit:1655465] Orlic-Milacic, Marija, 2011-10-12
[InstanceEdit:3662293] Orlic-Milacic, M, 2013-06-06
nameEGFR G719S
Epidermal Growth Factor Receptor G719S
EGFR Gly719Ser
referenceEntity[ReferenceGeneProduct:54208] UniProt:P00533 EGFR [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2017918] R-HSA-1169418.1
startCoordinate25
(hasComponent)[Complex:1169431] EGFR G719S mutant:gefitinib [plasma membrane] [Homo sapiens]
[Complex:1169625] EGFR G719S mutant dimer [plasma membrane] [Homo sapiens]
(hasMember)[CandidateSet:1176052] Ligand-responsive EGFR mutants sensitive to non-covalent TKIs [plasma membrane] [Homo sapiens]
[CandidateSet:1182972] EGFR G719X mutants [plasma membrane] [Homo sapiens]
(updatedInstance)[_UpdateTracker:9888410] Update Tracker - [EntityWithAccessionedSequence:1169418] EGFR G719S [plasma membrane] - v46:[modifyName]
[Change default viewing format]
No pathways have been reviewed or authored by EGFR G719S [plasma membrane] (1169418)