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Details on Person Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity

Class:Id	LiteratureReference:1169414
_displayName	Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity
_timestamp	2011-01-18 18:19:25
author	[Person:1169425] Yun, CH [Person:202244] Boggon, TJ [Person:1169423] Li, Y [Person:1169416] Woo, MS [Person:1169426] Greulich, Heidi [Person:1169419] Meyerson, M [Person:202355] Eck, MJ
created	[InstanceEdit:1169427] Orlic-Milacic, Marija, 2011-01-18
journal	Cancer Cell
pages	217-27
pubMedIdentifier	17349580
title	Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity
volume	11
year	2007
(literatureReference)	[CatalystActivityReference:9643325] protein tyrosine kinase activity of Active dimers of ligand-responsive EGFR mutants [plasma membrane] Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity [Summation:1169432] Small tyrosine kinase inhibitors (TKIs) from the anilinoquin... [Summation:1173215] EGFR ligand-responsive mutants dimerize spontaneously, witho... [Summation:1181054] G719X, a substitution of glycine 719 with alanine, cysteine ... [Summation:1181056] L858R, a substitution of leucine 858 with arginine, accounts... [Summation:1181169] Gefitinib (ZD1839, Iressa) is a low-molecular-weight EGFR ty... [Summation:1181246] Signaling by EGFR is frequently activated in cancer through ... [Reaction:1169421] Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers [Homo sapiens] [Pathway:1169434] Signaling by constitutively active EGFR kinase domain mutants [Homo sapiens] [Reaction:1220610] Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants [Homo sapiens] List all 29 refering instances
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