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Details on Person ISGylation of host proteins

Class:Id	Reaction:1169406
_displayName	ISGylation of host proteins
_doRelease	TRUE
_timestamp	2025-10-21 13:58:13
authored	[InstanceEdit:1169393] Garapati, P V, 2011-01-18
catalystActivity	[CatalystActivity:1169401] ISG15 ligase activity of ISG15:UBCH8:ISG15 E3 ligase [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1169393] Garapati, P V, 2011-01-18
edited	[InstanceEdit:1169393] Garapati, P V, 2011-01-18
input	[Complex:1169383] ISG15:UBCH8:ISG15 E3 ligase [cytosol] [Homo sapiens] [CandidateSet:1169379] ISG15 targets [cytosol] [Homo sapiens]
internalReviewed	[InstanceEdit:9969057] May, Bruce, 2025-10-21
isChimeric	FALSE
literatureReference	[LiteratureReference:1169329] High-throughput immunoblotting. Ubiquitiin-like protein ISG15 modifies key regulators of signal transduction [LiteratureReference:1015669] Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways [LiteratureReference:1169373] Proteomic identification of proteins conjugated to ISG15 in mouse and human cells
modified	[InstanceEdit:1213477] Garapati, P V, 2011-02-11 [InstanceEdit:1213480] Garapati, P V, 2011-02-11 [InstanceEdit:1220553] Garapati, P V, 2011-02-21 [InstanceEdit:1295508] Garapati, P V, 2011-05-16 [InstanceEdit:1307717] Matthews, L, 2011-05-28 [InstanceEdit:1500830] Garapati, P V, 2011-08-22 [InstanceEdit:1566927] Garapati, P V, 2011-09-06 [InstanceEdit:1678844] Garapati, P V, 2011-10-19 [InstanceEdit:1939605] Garapati, P V, 2011-11-03 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9968653] May, Bruce, 2025-10-19 [InstanceEdit:9969056] D'Eustachio, Peter, 2025-10-21 [InstanceEdit:9969060] D'Eustachio, Peter, 2025-10-21
name	ISGylation of host proteins
output	[Complex:1169387] ISGylated host proteins [cytosol] [Homo sapiens] [CandidateSet:1169381] ISG15 E3 ligases [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:936014] UBE2L6 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:1169403] Interaction of E3 ligase with ISG15:E2 complex [Homo sapiens] [Reaction:1169404] Transfer of ISG15 from E1 to E2 (UBCH8) [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2011-12-06
reviewed	[InstanceEdit:1213478] Zhang, DE, 2011-02-10 [InstanceEdit:9969059] D'Eustachio, Peter, 2025-10-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016456] R-HSA-1169406.3
structureModified	[InstanceEdit:9968653] May, Bruce, 2025-10-19
summation	[Summation:1169295] Many host proteins are targets for ISGylation including cons...
(hasEvent)	[Pathway:1169408] ISG15 antiviral mechanism [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9971879] Update Tracker - [Reaction:1169406] ISGylation of host proteins - v95:[addInput, addOutput]
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