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Details on Person Transfer of ISG15 from E1 to E2 (UBCH8)

Class:Id	Reaction:1169404
_displayName	Transfer of ISG15 from E1 to E2 (UBCH8)
_doRelease	TRUE
_timestamp	2011-11-23 11:12:06
authored	[InstanceEdit:1169393] Garapati, P V, 2011-01-18
catalystActivity	[CatalystActivity:1169400] ISG15 conjugating enzyme activity of UBE2L6 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643686] ISG15 conjugating enzyme activity of UBE2L6 [cytosol] Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylation
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1169393] Garapati, P V, 2011-01-18
edited	[InstanceEdit:1169393] Garapati, P V, 2011-01-18
input	[Complex:1169390] ISG15:UBA7 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:936014] UBE2L6 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1169365] The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein [LiteratureReference:1678819] Influenza B virus NS1 protein inhibits conjugation of the interferon (IFN)-induced ubiquitin-like ISG15 protein [LiteratureReference:1169315] Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylation [LiteratureReference:1169360] The basis for selective E1-E2 interactions in the ISG15 conjugation system
modified	[InstanceEdit:1213477] Garapati, P V, 2011-02-11 [InstanceEdit:1213480] Garapati, P V, 2011-02-11 [InstanceEdit:1220553] Garapati, P V, 2011-02-21 [InstanceEdit:1295508] Garapati, P V, 2011-05-16 [InstanceEdit:1307717] Matthews, L, 2011-05-28 [InstanceEdit:1500830] Garapati, P V, 2011-08-22 [InstanceEdit:1566928] Garapati, P V, 2011-09-06 [InstanceEdit:1678844] Garapati, P V, 2011-10-19 [InstanceEdit:1939605] Garapati, P V, 2011-11-03 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Transfer of ISG15 from E1 to E2 (UBCH8)
output	[Complex:1169385] ISG15:UBCH8 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:936550] UBA7 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:1169397] Activation of ISG15 by UBA7 E1 enzyme [Homo sapiens]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1213478] Zhang, DE, 2011-02-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016439] R-HSA-1169404.3
summation	[Summation:1169305] Activated ISG15 linked to UBE1L is transferred to the E2 con...
(hasEvent)	[Pathway:1169408] ISG15 antiviral mechanism [Homo sapiens]
(precedingEvent)	[Reaction:1169403] Interaction of E3 ligase with ISG15:E2 complex [Homo sapiens]
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