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Details on Person ISGylation of E2 conjugating enzymes

Class:IdReaction:1169402
_displayNameISGylation of E2 conjugating enzymes
_doReleaseTRUE
_timestamp2025-10-21 13:58:09
authored[InstanceEdit:1169393] Garapati, P V, 2011-01-18
catalystActivity[CatalystActivity:1169401] ISG15 ligase activity of ISG15:UBCH8:ISG15 E3 ligase [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:1169393] Garapati, P V, 2011-01-18
edited[InstanceEdit:1169393] Garapati, P V, 2011-01-18
input[Complex:1169383] ISG15:UBCH8:ISG15 E3 ligase [cytosol] [Homo sapiens]
[DefinedSet:1169378] E2 congugating enzymes [cytosol] [Homo sapiens]
internalReviewed[InstanceEdit:9969057] May, Bruce, 2025-10-21
isChimericFALSE
literatureReference[LiteratureReference:1169342] ISG15 modification of Ubc13 suppresses its ubiquitin-conjugating activity
[LiteratureReference:1169333] ISG15 modification of ubiquitin E2 Ubc13 disrupts its ability to form thioester bond with ubiquitin
[LiteratureReference:1169335] Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme
modified[InstanceEdit:1213477] Garapati, P V, 2011-02-11
[InstanceEdit:1213480] Garapati, P V, 2011-02-11
[InstanceEdit:1220553] Garapati, P V, 2011-02-21
[InstanceEdit:1295508] Garapati, P V, 2011-05-16
[InstanceEdit:1307716] Matthews, L, 2011-05-28
[InstanceEdit:1500830] Garapati, P V, 2011-08-22
[InstanceEdit:1566927] Garapati, P V, 2011-09-06
[InstanceEdit:1939605] Garapati, P V, 2011-11-03
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9968653] May, Bruce, 2025-10-19
[InstanceEdit:9969056] D'Eustachio, Peter, 2025-10-21
[InstanceEdit:9969060] D'Eustachio, Peter, 2025-10-21
nameISGylation of E2 conjugating enzymes
output[Complex:1169382] ISGylated E2 conjugating enzymes [cytosol] [Homo sapiens]
[CandidateSet:1169381] ISG15 E3 ligases [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:936014] UBE2L6 [cytosol] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2011-12-06
reviewed[InstanceEdit:1213478] Zhang, DE, 2011-02-10
[InstanceEdit:9969059] D'Eustachio, Peter, 2025-10-21
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2016109] R-HSA-1169402.3
structureModified[InstanceEdit:9968653] May, Bruce, 2025-10-19
summation[Summation:1169296] Ubiquitin conjugating E2 enzymes UBC13 and UBCH6 are targets...
(hasEvent)[Pathway:1169408] ISG15 antiviral mechanism [Homo sapiens]
(updatedInstance)[_UpdateTracker:9971945] Update Tracker - [Reaction:1169402] ISGylation of E2 conjugating enzymes - v95:[addInput, addOutput]
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No pathways have been reviewed or authored by ISGylation of E2 conjugating enzymes (1169402)
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