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Details on Person Activation of ISG15 by UBA7 E1 enzyme

Class:Id	Reaction:1169397
_displayName	Activation of ISG15 by UBA7 E1 enzyme
_doRelease	TRUE
_timestamp	2025-10-16 06:02:55
authored	[InstanceEdit:1169393] Garapati, P V, 2011-01-18
catalystActivity	[CatalystActivity:1169396] ISG15 activating enzyme activity of UBA7 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643547] ISG15 activating enzyme activity of UBA7 [cytosol] ISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important for innate immune control of Sindbis virus
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1169393] Garapati, P V, 2011-01-18
edited	[InstanceEdit:1169393] Garapati, P V, 2011-01-18
input	[EntityWithAccessionedSequence:936552] ISG15 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:936550] UBA7 [cytosol] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1169368] ISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important for innate immune control of Sindbis virus [LiteratureReference:1169360] The basis for selective E1-E2 interactions in the ISG15 conjugation system
modified	[InstanceEdit:1213477] Garapati, P V, 2011-02-11 [InstanceEdit:1213480] Garapati, P V, 2011-02-11 [InstanceEdit:1220553] Garapati, P V, 2011-02-21 [InstanceEdit:1295508] Garapati, P V, 2011-05-16 [InstanceEdit:1307713] Matthews, L, 2011-05-28 [InstanceEdit:1500830] Garapati, P V, 2011-08-22 [InstanceEdit:1566928] Garapati, P V, 2011-09-06 [InstanceEdit:1939605] Garapati, P V, 2011-11-03 [InstanceEdit:8983914] Jupe, Steve, 2017-03-31 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9968565] May, Bruce, 2025-10-16
name	Activation of ISG15 by UBA7 E1 enzyme
output	[Complex:1169390] ISG15:UBA7 [cytosol] [Homo sapiens] [SimpleEntity:76577] AMP [cytosol] [SimpleEntity:111294] PPi [cytosol]
releaseDate	2011-12-06
reviewed	[InstanceEdit:1213478] Zhang, DE, 2011-02-10
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2016698] R-HSA-1169397.5
summation	[Summation:1169287] Ubiquitin ligase UBE1L is the ISG15 activating enzyme. UBE1L...
(hasEvent)	[Pathway:1169408] ISG15 antiviral mechanism [Homo sapiens]
(precedingEvent)	[Reaction:1169404] Transfer of ISG15 from E1 to E2 (UBCH8) [Homo sapiens]
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No pathways have been reviewed or authored by Activation of ISG15 by UBA7 E1 enzyme (1169397)