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Details on Person ISGylation of viral protein NS1

Class:IdReaction:1169395
_displayNameISGylation of viral protein NS1
_doReleaseTRUE
_timestamp2025-10-21 13:58:17
authored[InstanceEdit:1169393] Garapati, P V, 2011-01-18
catalystActivity[CatalystActivity:1169401] ISG15 ligase activity of ISG15:UBCH8:ISG15 E3 ligase [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:1169393] Garapati, P V, 2011-01-18
edited[InstanceEdit:1169393] Garapati, P V, 2011-01-18
input[Complex:1169383] ISG15:UBCH8:ISG15 E3 ligase [cytosol] [Homo sapiens]
[Complex:169143] NS1 dimer [cytosol] [Influenza A virus]
internalReviewed[InstanceEdit:9969057] May, Bruce, 2025-10-21
isChimericFALSE
literatureReference[LiteratureReference:1169371] Species-specific antagonism of host ISGylation by the influenza B virus NS1 protein
[LiteratureReference:1169622] ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells
[LiteratureReference:1169623] Herc5 attenuates influenza A virus by catalyzing ISGylation of viral NS1 protein
modified[InstanceEdit:1169620] Garapati, P V, 2011-01-19
[InstanceEdit:1213477] Garapati, P V, 2011-02-11
[InstanceEdit:1213480] Garapati, P V, 2011-02-11
[InstanceEdit:1220553] Garapati, P V, 2011-02-21
[InstanceEdit:1295508] Garapati, P V, 2011-05-16
[InstanceEdit:1307717] Matthews, L, 2011-05-28
[InstanceEdit:1500830] Garapati, P V, 2011-08-22
[InstanceEdit:1566927] Garapati, P V, 2011-09-06
[InstanceEdit:1939605] Garapati, P V, 2011-11-03
[InstanceEdit:5621512] Matthews, Lisa, 2014-08-29
[InstanceEdit:6788897] Garapati, Phani Vijay, 2015-07-28
[InstanceEdit:9031715] D'Eustachio, Peter, 2017-12-01
[InstanceEdit:9031726] D'Eustachio, Peter, 2017-12-01
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9968653] May, Bruce, 2025-10-19
[InstanceEdit:9969056] D'Eustachio, Peter, 2025-10-21
[InstanceEdit:9969060] D'Eustachio, Peter, 2025-10-21
nameISGylation of viral protein NS1
output[Complex:1169392] ISGylated NS1 [cytosol] [Homo sapiens]
[CandidateSet:1169381] ISG15 E3 ligases [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:936014] UBE2L6 [cytosol] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
relatedSpecies[Species:9031716] Influenza A virus
releaseDate2011-12-06
reviewed[InstanceEdit:1213478] Zhang, DE, 2011-02-10
[InstanceEdit:9969059] D'Eustachio, Peter, 2025-10-21
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:2016531] R-HSA-1169395.5
structureModified[InstanceEdit:9968653] May, Bruce, 2025-10-19
summation[Summation:1169289] Some viral proteins are also targeted for ISGylation. The we...
(hasEvent)[Pathway:1169408] ISG15 antiviral mechanism [Homo sapiens]
(updatedInstance)[_UpdateTracker:9784085] Update Tracker - [Reaction:1169395] ISGylation of viral protein NS1 - v54:[add_removeInput]
[_UpdateTracker:9971839] Update Tracker - [Reaction:1169395] ISGylation of viral protein NS1 - v95:[addInput, addOutput]
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No pathways have been reviewed or authored by ISGylation of viral protein NS1 (1169395)
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