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Details on Person Phospholipase C gamma (PLC-gamma) is activated by phosphoryl...

Class:IdSummation:1168932
_displayNamePhospholipase C gamma (PLC-gamma) is activated by phosphoryl...
_timestamp2011-01-11 17:47:34
created[InstanceEdit:1168936] May, B, 2011-01-11
textPhospholipase C gamma (PLC-gamma) is activated by phosphorylation in response to antigen-binding by the B cell receptor (Carter et al. 1991, Roitman and Wang 1992, Rodriguez et al. 2001, Kim et al. 2004, Sekiya et al. 2004). Phospholipase C gamma hydrolyzes phosphatidylinositol-4,5-bisphosphate to yield inositol-1,4,5-trisphosphate and diacylglycerol (Carter et al. 1991, Kim et al. 2004). Human B cells contain both PLC-gamma1 and PLC-gamma2, with PLC-gamma2 predominating (Coggeshall et al. 1992).
(summation)[Reaction:1112666] BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate [Homo sapiens]
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