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Details on Person JAK2 phosphorylates STAT1/STAT3

Class:Id	Reaction:1168767
_displayName	JAK2 phosphorylates STAT1/STAT3
_doRelease	TRUE
_timestamp	2011-09-09 09:06:04
authored	[InstanceEdit:976955] Jupe, S, 2010-10-14
catalystActivity	[CatalystActivity:1169203] non-membrane spanning protein tyrosine kinase activity of Growth Hormone: Activated Growth Hormone Receptor:p(Y1007)-JAK2 dimer:STAT1/STAT3 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:1168782] Jupe, S, 2011-01-07
edited	[InstanceEdit:1362504] Jupe, S, 2011-06-10
inferredFrom	[Reaction:1169206] Jak2 phosphorylates Stat1/Stat3 [Mus musculus]
input	[Complex:1169146] Growth Hormone: Activated Growth Hormone Receptor:p(Y1007)-JAK2 dimer:STAT1/STAT3 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
modified	[InstanceEdit:1169190] Jupe, S, 2011-01-13 [InstanceEdit:1169269] Jupe, S, 2011-01-17 [InstanceEdit:1363242] Jupe, S, 2011-06-13 [InstanceEdit:1364048] Jupe, S, 2011-06-23 [InstanceEdit:1576229] Jupe, S, 2011-09-07 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	JAK2 phosphorylates STAT1/STAT3
output	[Complex:1169186] Growth Hormone: Activated Growth Hormone Receptor:p(Y1007)-JAK2 dimer:p(Y701)-STAT1/p(Y705)-STAT3 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:1168768] JAK2 binds STAT1/3 [Homo sapiens] [BlackBoxEvent:982810] JAK2 phosphorylation [Homo sapiens]
releaseDate	2011-09-20
reviewed	[InstanceEdit:1363241] Herington, AC, 2011-06-13 [InstanceEdit:1364056] Waters, MJ, 2011-06-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1591423] R-HSA-1168767.2
summation	[Summation:1168780] GH stimulated tyrosyl phosphorylation of Stats 1, 3, and 5 i...
(hasEvent)	[Pathway:982772] Growth hormone receptor signaling [Homo sapiens]
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No pathways have been reviewed or authored by JAK2 phosphorylates STAT1/STAT3 (1168767)