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Details on Person PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine

Class:Id	Reaction:1168373
_displayName	PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine
_doRelease	TRUE
_timestamp	2014-02-05 03:25:45
authored	[InstanceEdit:1168377] May, B, 2010-12-09
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:1168378] May, B, 2010-12-18
edited	[InstanceEdit:1168377] May, B, 2010-12-09
input	[EntityWithAccessionedSequence:58198] PRKCB [cytosol] [Homo sapiens] [SimpleEntity:114519] DAG [plasma membrane] [SimpleEntity:33625] PS [plasma membrane] [SimpleEntity:74016] Ca2+ [cytosol] [SimpleEntity:74016] Ca2+ [cytosol] [SimpleEntity:74016] Ca2+ [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1169032] Activation of purified human protein kinase C alpha and beta I isoenzymes in vitro by Ca2+, phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate [LiteratureReference:1168965] Immunodeficiency in protein kinase cbeta-deficient mice [LiteratureReference:1168953] PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling [LiteratureReference:1169014] Protein kinase C beta controls nuclear factor kappaB activation in B cells through selective regulation of the IkappaB kinase alpha
modified	[InstanceEdit:1168379] May, B, 2010-12-18 [InstanceEdit:1169093] May, B, 2011-01-11 [InstanceEdit:1977928] May, B, 2011-11-08 [InstanceEdit:2010554] May, B, 2011-11-22 [InstanceEdit:2108989] May, B, 2012-02-11 [InstanceEdit:5251728] May, B, 2014-02-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine Protein Kinase C beta (PKC-beta, PRKCB) is activated
output	[Complex:139829] Activated PKC beta [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:434798] CRAC translocates calcium from the extracellular region to the cytosol [Homo sapiens] [Reaction:434700] STIM1 activation of CRAC [Homo sapiens] [Reaction:1112666] BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate [Homo sapiens] [Reaction:9606162] Phosphorylated BTK phosphorylates PLCG2 [Homo sapiens] [Reaction:169683] IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol [Homo sapiens] [Reaction:169680] IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel [Homo sapiens] [Reaction:167686] Active PLCG1 hydrolyses PIP2 [Homo sapiens]
releaseDate	2012-03-13
reviewed	[InstanceEdit:2108988] Wienands, J, 2012-02-11
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:2158178] R-HSA-1168373.2
summation	[Summation:1168934] Human Protein kinase C beta (PKC-beta) is activated by calci...
(hasEvent)	[Pathway:1169091] Activation of NF-kappaB in B cells [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:1168635] PRKCB (PKC-beta) phosphorylates CARMA1 [Homo sapiens]
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No pathways have been reviewed or authored by PRKCB (Protein kinase C beta, PKC-beta) binds diacylglycerol and phosphatidylserine (1168373)