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Details on Person Classical models of GHR activation suggest that GH binds seq...
| Class:Id | Summation:1168345 |
|---|---|
| _displayName | Classical models of GHR activation suggest that GH binds seq... |
| _timestamp | 2011-06-23 14:50:32 |
| created | [InstanceEdit:1168344] Jupe, S, 2010-12-17 |
| literatureReference | [LiteratureReference:982797] Model for growth hormone receptor activation based on subunit rotation within a receptor dimer [LiteratureReference:1168346] Turning the growth hormone receptor on: evidence that hormone binding induces subunit rotation [LiteratureReference:1364060] Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation [LiteratureReference:1168395] An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway [LiteratureReference:1168415] The growth hormone receptor: mechanism of activation and clinical implications |
| modified | [InstanceEdit:1168348] Jupe, S, 2010-12-17 [InstanceEdit:1168383] Jupe, S, 2010-12-20 [InstanceEdit:1168386] Jupe, S, 2010-12-20 [InstanceEdit:1168430] Jupe, S, 2010-12-21 [InstanceEdit:1364048] Jupe, S, 2011-06-23 |
| text | Classical models of GHR activation suggest that GH binds sequentially to two GHR molecules, leading to receptor dimerization and activation. More recently, evidence from FRET, BRET, Co-IP (Brown et al. 2005) and molecular simulations (Poger & Mark 2010) suggest that dimerization occurs before ligand binding, and that activation is a consequence of conformational changes caused by ligand binding, namely a relative rotation of the receptor dimer so that the catalytic domains of JAK2 molecules bound to the cytoplasmic tails are brought into close proximity and are consequently able to phosphorylate each other (Rowlinson et al. 2008). Realignment of the receptor subunits and consequent JAK2 activation is supported by crystal structures of the related erythropoietin receptor (Livnah et al. 1999); similar proposals have been made for many receptors, including the prolactin and erythropoietin receptors (Brooks & Waters 2010). |
| (summation) | [BlackBoxEvent:982768] GH:GHR:JAK2 complex undergoes a conformational change [Homo sapiens] |
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