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Details on Person UniProt:Q67W29 DAPB1
| Class:Id | ReferenceGeneProduct:1159839 |
|---|---|
| _chainChangeLog | transit peptide:1-14 added on Sat February 7 2015;chain:15-343 added on Sat February 7 2015 |
| _displayName | UniProt:Q67W29 DAPB1 |
| _timestamp | 2025-02-21 19:26:51 |
| chain | transit peptide:1-14 chain:15-343 |
| checksum | 93D85B900A9C247A |
| comment | FUNCTION Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.CATALYTIC ACTIVITY (S)-2,3,4,5-tetrahydrodipicolinate + NAD(+) + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H(+)CATALYTIC ACTIVITY (S)-2,3,4,5-tetrahydrodipicolinate + NADP(+) + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H(+)PATHWAY Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.SUBCELLULAR LOCATION Belongs to the DapB family.CAUTION Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction. |
| created | [InstanceEdit:1164949] Wu, Guanming, 2010-12-11 |
| crossReference | [DatabaseIdentifier:1148520] UniProtKB:B7EB68 [DatabaseIdentifier:1147899] UniProtKB:Q67W29 [DatabaseIdentifier:1143526] UniProtKB:B8AGP3 |
| description | recommendedName: Probable 4-hydroxy-tetrahydrodipicolinate reductase 1, chloroplastic shortName: HTPA reductase 1 ecNumber: 1.17.1.8 |
| geneName | DAPB1 Os02g0436400 LOC_Os02g24020 OJ1126_B05.33 OsJ_006340 OsJ_06538 |
| identifier | Q67W29 |
| isSequenceChanged | FALSE |
| keyword | Amino-acid biosynthesis Chloroplast Diaminopimelate biosynthesis Lysine biosynthesis NAD NADP Oxidoreductase Plastid Reference proteome Transit peptide |
| modified | [InstanceEdit:2879972] D'Eustachio, P, 2012-12-26 [InstanceEdit:3132113] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8934940] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | DAPB1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | DAPB1_ORYSJ A3A6B8 B7EB68 |
| sequenceLength | 343 |
| species | [Species:1250427] Oryza sativa subsp. japonica |
| (referenceEntity) | [EntityWithAccessionedSequence:1129184] dihydrodipicolinate reductase (LOC_OS02G24020.1) [cytosol] [Oryza sativa] [EntityWithAccessionedSequence:5606505] dihydrodipicolinate reductase (LOC_OS02G24020.1) [plastid stroma] [Oryza sativa] |
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No pathways have been reviewed or authored by UniProt:Q67W29 DAPB1 (1159839)
