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Details on Person UniProt:Q6ZD89 COMT
| Class:Id | ReferenceGeneProduct:1159587 |
|---|---|
| _chainChangeLog | propeptide:1-2 added on Sat February 7 2015;chain:3-368 added on Sat February 7 2015 |
| _displayName | UniProt:Q6ZD89 COMT |
| _timestamp | 2025-02-21 19:30:36 |
| chain | propeptide:1-2 chain:3-368 |
| checksum | 2491B4FA7447558E |
| comment | FUNCTION Methylates OH residues of flavonoid compounds. Can methylate eriodictyol, luteolin, quercetin and taxifolin (PubMed:16412485). Methylates caffeate to produce ferrulate (PubMed:21210840, Ref.16). Catalyzes the methylation of monolignols, the lignin precursors. Functions cooperatively with CAD2 in the culm internodes for the biosynthesis of monolignols. May be involved in lignin biosynthesis in leaves and roots (PubMed:21912859). Involved in syringyl lignin biosynthesis. Can function as 5-hydroxyconiferaldehyde O-methyltransferase in the biosynthetic pathway to syringyl lignin (Ref.16). Involved in melatonin biosynthesis. Can function as acetylserotonin O-methyltransferase. Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine) (PubMed:26276868).CATALYTIC ACTIVITY a 3'-hydroxyflavone + S-adenosyl-L-methionine = a 3'-methoxyflavone + S-adenosyl-L-homocysteine + H(+)CATALYTIC ACTIVITY N-acetylserotonin + S-adenosyl-L-methionine = melatonin + S-adenosyl-L-homocysteine + H(+)CATALYTIC ACTIVITY (E)-caffeate + S-adenosyl-L-methionine = (E)-ferulate + S-adenosyl-L-homocysteine + H(+)ACTIVITY REGULATION Acetylserotonin O-methyltransferase activity is inhibited by quercetin and caffeate.BIOPHYSICOCHEMICAL PROPERTIES Measured at pH 7.5 and 37 degrees Celsius for all experiments.PATHWAY Flavonoid metabolism; quercetin degradation.SUBUNIT Monomer.SUBCELLULAR LOCATION Expressed in roots and stems, and at lower levels in leaves.INDUCTION By probenazole (at protein level) (PubMed:17950386). Induced by UV-C (PubMed:24035516).SIMILARITY Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.CAUTION Was initially thought to constitute the naringenin 7-O-methyltransferase (NOMT), a methyltransferase involved in the biosynthesis of the sakuranetin, an inducible defense mechanism of O.sativa against pathogen attack (PubMed:10814825). However, it was later shown that it is not the case (PubMed:22493492).SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:1164949] Wu, Guanming, 2010-12-11 |
| crossReference | [DatabaseIdentifier:1141703] UniProtKB:A2YRE2 [DatabaseIdentifier:1145114] UniProtKB:Q19BJ6 [DatabaseIdentifier:1146574] UniProtKB:Q6ZD89 [DatabaseIdentifier:1147226] UniProtKB:A3BPT2 |
| description | recommendedName: fullName evidence="16"Flavone 3'-O-methyltransferase 1 shortName evidence="16"OsOMT1 ecNumber evidence="5"2.1.1.42 alternativeName: fullName evidence="16"Acetylserotonin O-methyltransferase COMT ecNumber evidence="11"2.1.1.4 alternativeName: fullName evidence="16"Caffeate O-methyltransferase 1 shortName evidence="15"OsCOMT1 ecNumber evidence="12"2.1.1.68 alternativeName: fullName evidence="14"OsCOMT alternativeName: fullName evidence="16"Quercetin 3'-O-methyltransferase 1 |
| geneName | COMT ROMT-9 Os08g0157500 LOC_Os08g06100 OsJ_26105 P0438H08.29 |
| identifier | Q6ZD89 |
| isSequenceChanged | FALSE |
| keyword | Cytoplasm Direct protein sequencing Melatonin biosynthesis Methyltransferase Reference proteome S-adenosyl-L-methionine Transferase |
| modified | [InstanceEdit:1251358] D'Eustachio, P, 2011-04-25 [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5083144] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8934940] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | COMT |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | OMT1_ORYSJ A0A0P0XBV5 A3BPT2 Q19BJ6 Q75W57 |
| sequenceLength | 368 |
| species | [Species:1250427] Oryza sativa subsp. japonica |
| (referenceEntity) | [EntityWithAccessionedSequence:1126515] O-methyltransferase (LOC_OS08G06100.1) [cytosol] [Oryza sativa subsp. japonica] [EntityWithAccessionedSequence:9609608] ROMT-9 [cytosol] [Oryza sativa] [EntityWithAccessionedSequence:9916171] OsOMT [cytosol] [Oryza sativa] [EntityWithAccessionedSequence:9916312] OsOMT [nucleoplasm] [Oryza sativa] |
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No pathways have been reviewed or authored by UniProt:Q6ZD89 COMT (1159587)
