Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q8LM92 CYP75B4
| Class:Id | ReferenceGeneProduct:1159259 |
|---|---|
| _displayName | UniProt:Q8LM92 CYP75B4 |
| _timestamp | 2025-08-15 22:15:22 |
| chain | chain:1-535 |
| checksum | 9AB17D2B9A86B6F1 |
| comment | FUNCTION Catalyzes the 3'-hydroxylation of the flavonoid B-ring to the 3',4'-hydroxylated state. Catalyzes in vitro 3'-hydroxylation of different flavonoids. Catalyzes the conversion of apigenin to luteolin, naringenin to eriodictyol, and kaempferol to quercetin. Possesses specific 5'-hydroxylase activity toward chrysoeriol (a 3'-methoxylated flavone) and is indispensable for tricin formation. Converts chrysoeriol to selgin, a precursor of tricin, suggesting that chrysoeriol, instead of tricetin, is an intermediate in tricin biosynthesis.CATALYTIC ACTIVITY a 3'-unsubstituted flavone + reduced [NADPH--hemoprotein reductase] + O2 = a 3'-hydroxyflavone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)COFACTOR Secondary metabolite biosynthesis; flavonoid biosynthesis.SUBCELLULAR LOCATION Belongs to the cytochrome P450 family. |
| created | [InstanceEdit:1164949] Wu, Guanming, 2010-12-11 |
| crossReference | [DatabaseIdentifier:1146363] UniProtKB:Q8LM92 [DatabaseIdentifier:1140260] UniProtKB:A2Z5X0 |
| description | recommendedName: fullName evidence="5"Flavonoid 3'-monooxygenase CYP75B4 ecNumber evidence="3"1.14.14.82 alternativeName: fullName evidence="4"Chrysoeriol 5'-hydroxylase alternativeName: fullName evidence="4"Cytochrome P450 75B4 alternativeName: fullName evidence="4"Flavonoid 3'-hydroxylase CYP75B4 |
| geneName | CYP75B4 Os10g0317900 LOC_Os10g16974 OSJNBb0079E01.10 |
| identifier | Q8LM92 |
| isSequenceChanged | FALSE |
| keyword | Flavonoid biosynthesis Heme Iron Membrane Metal-binding Monooxygenase NADP Oxidoreductase Reference proteome Transmembrane Transmembrane helix |
| modified | [InstanceEdit:1251358] D'Eustachio, P, 2011-04-25 [InstanceEdit:2672435] D'Eustachio, P, 2012-11-27 [InstanceEdit:9015733] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9616384] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | CYP75B4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | C75B4_ORYSJ |
| sequenceLength | 535 |
| species | [Species:1250427] Oryza sativa subsp. japonica |
| (referenceEntity) | [EntityWithAccessionedSequence:1128178] flavonoid-3-hydroxylase (LOC_OS10G16974.1) [cytosol] [Oryza sativa] [EntityWithAccessionedSequence:9609575] CYP75B4 [endoplasmic reticulum membrane] [Oryza sativa] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q8LM92 CYP75B4 (1159259)
