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Details on Person UniProt:Q10P67 DAPB2
| Class:Id | ReferenceGeneProduct:1157949 |
|---|---|
| _chainChangeLog | transit peptide:1-32 added on Fri February 6 2015;chain:33-325 added on Fri February 6 2015 |
| _displayName | UniProt:Q10P67 DAPB2 |
| _timestamp | 2025-02-21 19:26:51 |
| chain | transit peptide:1-32 chain:33-325 |
| checksum | E1A4D87189A0585F |
| comment | FUNCTION Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.CATALYTIC ACTIVITY (S)-2,3,4,5-tetrahydrodipicolinate + NAD(+) + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H(+)CATALYTIC ACTIVITY (S)-2,3,4,5-tetrahydrodipicolinate + NADP(+) + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H(+)PATHWAY Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.SUBCELLULAR LOCATION Belongs to the DapB family.CAUTION Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction. |
| created | [InstanceEdit:1164949] Wu, Guanming, 2010-12-11 |
| crossReference | [DatabaseIdentifier:1137803] UniProtKB:B7ESW8 [DatabaseIdentifier:1139979] UniProtKB:B7E3L9 [DatabaseIdentifier:1139178] UniProtKB:B8AK10 [DatabaseIdentifier:1135552] UniProtKB:Q10P67 |
| description | recommendedName: Probable 4-hydroxy-tetrahydrodipicolinate reductase 2, chloroplastic shortName: HTPA reductase 2 ecNumber: 1.17.1.8 |
| geneName | DAPB2 Os03g0245100 LOC_Os03g14120 OsJ_009732 OsJ_10116 |
| identifier | Q10P67 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Amino-acid biosynthesis Chloroplast Diaminopimelate biosynthesis Lysine biosynthesis NAD NADP Oxidoreductase Plastid Reference proteome Transit peptide |
| modified | [InstanceEdit:2879972] D'Eustachio, P, 2012-12-26 [InstanceEdit:3132113] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8934940] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | DAPB2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | DAPB2_ORYSJ A3AG10 B7ESW8 Q0DTI8 Q10P66 |
| sequenceLength | 325 |
| species | [Species:1250427] Oryza sativa subsp. japonica |
| (isoformParent) | [ReferenceIsoform:8977372] UniProt:Q10P67-1 DAPB2 [Oryza sativa subsp. japonica] [ReferenceIsoform:8977373] UniProt:Q10P67-2 DAPB2 [Oryza sativa subsp. japonica] |
| (referenceEntity) | [EntityWithAccessionedSequence:1125870] dihydrodipicolinate reductase (LOC_OS03G14120.1) [cytosol] [Oryza sativa] [EntityWithAccessionedSequence:5606480] dihydrodipicolinate reductase (LOC_OS03G14120.1) [plastid stroma] [Oryza sativa] |
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No pathways have been reviewed or authored by UniProt:Q10P67 DAPB2 (1157949)
