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Details on Person UniProt:Q5CCK3 CYP90B2
| Class:Id | ReferenceGeneProduct:1157127 |
|---|---|
| _chainChangeLog | chain:1-506 added on Fri February 17 2017 |
| _displayName | UniProt:Q5CCK3 CYP90B2 |
| _timestamp | 2025-02-21 18:34:30 |
| chain | chain:1-506 |
| checksum | 68E733DA80556B9F |
| comment | FUNCTION Catalyzes the C22-alpha-hydroxylation step in brassinosteroid biosynthesis, which is the rate-limiting step in this biosynthetic pathway (PubMed:16369540). Catalyzes the conversion of campesterol (CR) to (22S)-22-hydroxycampesterol (22-OHCR, 22-hydroxyCR) and of campestanol (CN) to 6-deoxycathasterone (6-deoxoCT) (PubMed:16369540). Required for auxin responses involved in the regulation of epidermal cells length of the lamina joint (PubMed:19605414).CATALYTIC ACTIVITY a C28-steroid + reduced [NADPH--hemoprotein reductase] + O2 = a (22S)-22-hydroxy C28-steroid + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)CATALYTIC ACTIVITY campesterol + reduced [NADPH--hemoprotein reductase] + O2 = (22S)-22-hydroxycampesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)CATALYTIC ACTIVITY campestanol + reduced [NADPH--hemoprotein reductase] + O2 = 6-deoxycathasterone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)COFACTOR Plant hormone biosynthesis; brassinosteroid biosynthesis.SUBCELLULAR LOCATION Highly expressed in roots and leaf blades. Expressed in shoot apex, stems, leaf sheaths, inflorescences and flowers.INDUCTION Down-regulated by brassinolide (BL).DISRUPTION PHENOTYPE Slight dwarf phenotype and erect leaves (PubMed:16369540). Impaired response to auxin leading to reduced epidermal cells length of the lamina joint (PubMed:19605414).BIOTECHNOLOGY Null mutant plants for CYP90B1/DWARF4 produce increased biomass and grain yield at high density planting.SIMILARITY Belongs to the cytochrome P450 family.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:1164949] Wu, Guanming, 2010-12-11 |
| crossReference | [DatabaseIdentifier:1140591] UniProtKB:Q8H848 [DatabaseIdentifier:1139883] UniProtKB:Q5CCK3 [DatabaseIdentifier:1140834] UniProtKB:B8AJL3 |
| description | recommendedName: fullName evidence="7"Steroid (22S)-hydroxylase ecNumber evidence="3"1.14.14.178 alternativeName: fullName evidence="5"(22S)-22-hydroxycampesterol synthase alternativeName: fullName evidence="5"6-deoxycathasterone synthase alternativeName: fullName evidence="7"Cytochrome P450 90B2 shortName evidence="7"OsCYP90B2 alternativeName: fullName evidence="5"Protein DWARF4 homolog shortName evidence="5 6"OsDWARF4 alternativeName: fullName evidence="7"Steroid 22-alpha-hydroxylase |
| geneName | CYP90B2 CYP90B1 DWARF4 Os03g0227700 LOC_Os03g12660 OJ1626B05.9 |
| identifier | Q5CCK3 |
| isSequenceChanged | FALSE |
| keyword | Brassinosteroid biosynthesis Heme Iron Lipid biosynthesis Lipid metabolism Membrane Metal-binding Monooxygenase Oxidoreductase Reference proteome Steroid biosynthesis Transmembrane Transmembrane helix |
| modified | [InstanceEdit:2730779] Amarasinghe, V, 2012-12-04 [InstanceEdit:8964659] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9796772] Weiser, Joel [InstanceEdit:9829221] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | CYP90B2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | C90B2_ORYSJ Q8H848 |
| sequenceLength | 506 |
| species | [Species:1250427] Oryza sativa subsp. japonica |
| (referenceEntity) | [EntityWithAccessionedSequence:1128501] campesterol 22alpha-hydroxylase like cytochrome P450 (LOC_OS03G12660.1) [cytosol] [Oryza sativa] |
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No pathways have been reviewed or authored by UniProt:Q5CCK3 CYP90B2 (1157127)
