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Details on Person UniProt:Q6ZHS4 CAD2
| Class:Id | ReferenceGeneProduct:1155594 |
|---|---|
| _chainChangeLog | chain:1-363 added on Fri February 6 2015 |
| _displayName | UniProt:Q6ZHS4 CAD2 |
| _timestamp | 2025-02-21 19:16:04 |
| chain | chain:1-363 |
| checksum | EFD21231AFB35B4B |
| comment | FUNCTION Involved in lignin biosynthesis (PubMed:16443696, PubMed:21912859). Catalyzes the final step specific for the production of lignin monomers. Catalyzes the NADPH-dependent reduction of coniferaldehyde and sinapaldehyde to their respective alcohols (PubMed:16443696). Plays the major role in monolignol biosynthesis. Functions cooperatively with COMT in the culm internodes for the biosynthesis of monolignols, the lignin precursors. May be involved in lignin biosynthesis in leaves and roots (PubMed:21912859).CATALYTIC ACTIVITY (E)-cinnamyl alcohol + NADP(+) = (E)-cinnamaldehyde + NADPH + H(+)CATALYTIC ACTIVITY (E)-coniferol + NADP(+) = (E)-coniferaldehyde + NADPH + H(+)CATALYTIC ACTIVITY (E)-sinapyl alcohol + NADP(+) = (E)-sinapaldehyde + NADPH + H(+)CATALYTIC ACTIVITY (E)-4-coumaroyl alcohol + NADP(+) = (E)-4-coumaraldehyde + NADPH + H(+)CATALYTIC ACTIVITY (E)-caffeyl alcohol + NADP(+) = (E)-caffeyl aldehyde + NADPH + H(+)COFACTOR Binds 2 Zn(2+) ions per subunit.BIOPHYSICOCHEMICAL PROPERTIES Aromatic compound metabolism; phenylpropanoid biosynthesis.SUBUNIT Homodimer.TISSUE SPECIFICITY Expressed in roots behind the root tips in the pericycle region and layer of cortical cells adjacent to the exodermis. Expressed in vascular bundles and lateral veins of leaf sheaths and blades. Expressed in the vicinity of vascular bundles in the first internode below the inflorescence (PubMed:15452707, PubMed:16443696). Highly expressed in the culm (PubMed:21912859).DISRUPTION PHENOTYPE Reduced lignin content, reddish-brown coloration of panicles and internodes, and golden yellow seeds.SIMILARITY Belongs to the zinc-containing alcohol dehydrogenase family. |
| created | [InstanceEdit:1164949] Wu, Guanming, 2010-12-11 |
| crossReference | [DatabaseIdentifier:1139576] UniProtKB:Q38G74 [DatabaseIdentifier:1140268] UniProtKB:A3A3Y3 [DatabaseIdentifier:1143245] UniProtKB:Q6ZHS4 [DatabaseIdentifier:1138394] UniProtKB:Q75W59 |
| description | recommendedName: fullName evidence="7"Cinnamyl alcohol dehydrogenase 2 shortName evidence="5"OsCAD2 ecNumber evidence="3"1.1.1.195 alternativeName: fullName evidence="6"Protein GOLD HULL AND INTERNODE 2 |
| geneName | CAD2 CAD GH2 Os02g0187800 LOC_Os02g09490 OJ1073_F05.31 OJ1145_F01.6 |
| identifier | Q6ZHS4 |
| isSequenceChanged | FALSE |
| keyword | Lignin biosynthesis Metal-binding NADP Oxidoreductase Reference proteome Zinc |
| modified | [InstanceEdit:2958711] D'Eustachio, P, 2013-01-04 [InstanceEdit:3132113] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8934940] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | CAD2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CADH2_ORYSJ A0A0N7KEU2 Q75W59 |
| sequenceLength | 363 |
| species | [Species:1250427] Oryza sativa subsp. japonica |
| (referenceEntity) | [EntityWithAccessionedSequence:1125967] cinnamyl alcohol dehydrogenase (LOC_OS02G09490.1) [cytosol] [Oryza sativa] |
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No pathways have been reviewed or authored by UniProt:Q6ZHS4 CAD2 (1155594)
