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Details on Person Activated thrombin (factor IIa) cleaves PAR3,4, activating them

Class:IdReaction:114697
_displayNameActivated thrombin (factor IIa) cleaves PAR3,4, activating them
_doReleaseTRUE
_timestamp2020-12-02 14:21:40
authored[InstanceEdit:141659] de Bono, B, Pace, N.P., Farndale, R, 2004-09-25 17:06:19
catalystActivity[CatalystActivity:139890] serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region]
compartment[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created[InstanceEdit:141659] de Bono, B, Pace, N.P., Farndale, R, 2004-09-25 17:06:19
edited[InstanceEdit:141659] de Bono, B, Pace, N.P., Farndale, R, 2004-09-25 17:06:19
input[DefinedSet:453302] PAR3, 4 [plasma membrane] [Homo sapiens]
literatureReference[LiteratureReference:140151] Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
[LiteratureReference:140157] Protease-activated receptor 3 is a second thrombin receptor in humans
[LiteratureReference:140075] Cloning and characterization of human protease-activated receptor 4
modified[InstanceEdit:139825] de Bono, B, 2004-08-09 09:46:05
[InstanceEdit:139985] de Bono, B, 2004-08-12 05:56:15
[InstanceEdit:141660] de Bono, B, 2004-09-25 21:06:36
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:194433] Schmidt, EE, 2007-03-13 12:36:50
[InstanceEdit:397904] Jupe, S, 2009-03-13 16:25:15
[InstanceEdit:416496] Jupe, S, 2009-03-27 14:27:46
[InstanceEdit:418590] Jupe, S, 2009-04-24 10:10:44
[InstanceEdit:421600] Jupe, S, 2009-05-19 09:16:39
[InstanceEdit:425512] Jupe, S, 2009-06-04
[InstanceEdit:427842] Jupe, S, 2009-06-29
[InstanceEdit:453304] Jupe, S, 2010-01-21
[InstanceEdit:456933] Jupe, S, 2010-01-22
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9708864] Jassal, Bijay, 2020-12-02
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameActivated thrombin (factor IIa) cleaves PAR3,4, activating them
Thrombin-mediated activation of Proteinase-activated receptors
output[DefinedSet:114530] Thrombin-activated PARs [plasma membrane] [Homo sapiens]
[DefinedSet:453303] PAR N-teminal fragments [extracellular region] [Homo sapiens]
releaseDate2004-07-06
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361785] R-HSA-114697.4
summation[Summation:397907] Thrombin signaling is mediated at least in part by a small f...
(hasEvent)[Pathway:456926] Thrombin signalling through proteinase activated receptors (PARs) [Homo sapiens]
(precedingEvent)[Reaction:396941] Thrombin-activated PARs binds G-protein G12/13 [Homo sapiens]
[Reaction:396996] Thrombin-activated PARs binds G-protein Gq [Homo sapiens]
[Reaction:418091] F2R binds ARRB1 [Homo sapiens]
[Reaction:418172] F2R binds ARRB2 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9790887] Update Tracker - [Reaction:114697] Activated thrombin (factor IIa) cleaves PAR3,4, activating them - v32:[addLiteratureReference, add_removeInput, add_removeOutput, add_removeSummation]
[_UpdateTracker:9791445] Update Tracker - [Reaction:114697] Activated thrombin (factor IIa) cleaves PAR3,4, activating them - v30:[add_removeOutput]
[_UpdateTracker:9791508] Update Tracker - [Reaction:114697] Activated thrombin (factor IIa) cleaves PAR3,4, activating them - v29:[add_removeOutput]
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