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Details on Person PLC-beta hydrolyses PIP2 to DAG and IP3

Class:IdReaction:114688
_displayNamePLC-beta hydrolyses PIP2 to DAG and IP3
_doReleaseTRUE
_timestamp2019-10-25 13:01:47
catalystActivity[CatalystActivity:139838] C-type glycerophospholipase activity of PLC beta:G alpha (q/11) [plasma membrane]
compartment[Compartment:876] plasma membrane
created[InstanceEdit:141659] de Bono, B, Pace, N.P., Farndale, R, 2004-09-25 17:06:19
edited[InstanceEdit:435382] Jupe, S, 2009-09-09
input[Complex:8983508] PLC-beta:G-alpha(q/11):PIP2 [plasma membrane] [Homo sapiens]
literatureReference[LiteratureReference:140093] Purification and characterization of membrane-bound phospholipase C specific for phosphoinositides from human platelets
[LiteratureReference:425757] Structure, function, and control of phosphoinositide-specific phospholipase C
modified[InstanceEdit:139825] de Bono, B, 2004-08-09 09:46:05
[InstanceEdit:139985] de Bono, B, 2004-08-12 05:56:15
[InstanceEdit:141660] de Bono, B, 2004-09-25 21:06:36
[InstanceEdit:163376] Vastrik, I, 2005-04-29 06:26:51
[InstanceEdit:398189] Jupe, S, 2009-03-18 10:29:41
[InstanceEdit:418226] Jupe, S, 2009-04-17 15:51:27
[InstanceEdit:421590] Jupe, S, 2009-05-19 08:57:17
[InstanceEdit:422154] D'Eustachio, P, 2009-05-26 22:22:55
[InstanceEdit:425199] Jassal, Bijay, 2009-06-03
[InstanceEdit:430228] Jupe, S, 2009-08-05
[InstanceEdit:435383] Jupe, S, 2009-09-09
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:2851312] Jupe, S, 2012-12-13
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:8983501] Varusai, Thawfeek, 2017-03-24
[InstanceEdit:9007062] Varusai, Thawfeek, 2017-05-26
[InstanceEdit:9012089] Varusai, Thawfeek, 2017-07-11
[InstanceEdit:9016522] Varusai, Thawfeek, 2017-08-14
[InstanceEdit:9664489] Murillo, Julieth, 2019-10-23
[InstanceEdit:9664534] Murillo, Julieth, 2019-10-25
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePLC-beta hydrolyses PIP2 to DAG and IP3
output[Complex:8983509] PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2004-07-06
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:9012014] Varusai, Thawfeek, 2017-07-10
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358668] R-HSA-114688.6
summation[Summation:425758] Phospholipase C (PLC) isozymes are a group of related protei...
(hasEvent)[Pathway:416476] G alpha (q) signalling events [Homo sapiens]
(precedingEvent)[Reaction:114553] Activation of conventional Protein Kinase C [Homo sapiens]
[Reaction:139941] Binding of IP3 to IP3 receptor [Homo sapiens]
[Reaction:392831] Calcium and Diacylglycerol activate CalDAG-GEFs (RasGRPs) [Homo sapiens]
[Reaction:425861] Activation of Protein Kinase C novel isoforms [Homo sapiens]
[Reaction:426032] DAG is metabolized by DAGL to 2-AG [Homo sapiens]
[Reaction:426209] DAG activation of TRPC channels [Homo sapiens]
[Reaction:426240] DAG kinase produces phosphatidic acid from DAG [Homo sapiens]
[Reaction:8983503] PLC-beta:G-alpha(q/11):DAG:IP3 dissociates to give DAG and IP3 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9781160] Update Tracker - [Reaction:114688] PLC-beta hydrolyses PIP2 to DAG and IP3 - v61:[addLiteratureReference, add_removeInput, add_removeOutput]
[_UpdateTracker:9788105] Update Tracker - [Reaction:114688] PLC-beta hydrolyses PIP2 to DAG and IP3 - v44:[add_removeInput]
[_UpdateTracker:9791452] Update Tracker - [Reaction:114688] PLC-beta hydrolyses PIP2 to DAG and IP3 - v30:[add_removeSummation]
[_UpdateTracker:9791527] Update Tracker - [Reaction:114688] PLC-beta hydrolyses PIP2 to DAG and IP3 - v29:[modifyText]
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